St. Nicholas Greek Orthodox Cathedral

Tarpon Springs is known for elaborate religious ceremonies related to the Greek Orthodox Church such as Epiphany celebrated every January 6 with the blessing of the waters and the boats. Since the livelihood of the initial Greek immigrants hinged around the sea and their boats, their attachment to a religious service centered on requesting divine protection for what used to be a highly risky job can be easily explained.

The celebration attracts Greek Americans from across the country, and the city's population is known to triple in size for that day. The Metropolitan of Atlanta usually presides over the blessings, sometimes joined by the Archbishop of America. The blessings conclude with the ceremonial throwing of a wooden cross into the city's Spring Bayou, and boys ages 1618 dive in to retrieve it: whoever recovers the cross is said to be blessed for a full year. Following the blessings, the celebration moves to the Sponge Docks where food and music are made part of the festivities.

On January 6, 2006, the 100th anniversary celebration of the Epiphany services in Tarpon Springs was the occasion for a visit by his all-holiness, Bartholomew I, the Patriarch of Constantinople, who is considered "first among equals" of all hierarchs of the Orthodox Church. He presided over the Epiphany services in one of the few visits to America by an Ecumenical Patriarch.