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Hi Rebecca,
It sounds like a fun trip you're planning for you and your boys. I live and work in downtown Chicago and can give you some good information. First, the Navy Pier trollies are still running. They run from Navy Pier to State Street and back. The Courtyard by Marriott Downtown/River North (30 E. Hubbard) is on State Street and has the Navy Pier trolley stop directly behind it. Second, the CTA #10 bus will take you and your boys to the front door of the Museum of Science and Industry. There are two #10 bus stops within walking disance of that hotel; one at Michigan/Chicago and the other at State/Lake. I believe the free trolley service that ran between downtown and the Museum of Science and Industry has been discontinued. You might also want to consider the Hilton Garden Inn, 10 E. Grand, which is only two blocks north of the Courtyard.
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