Mt Adams: Check out MtAdams and the little pockets of neighborhoods surrounding Eden Park. I would say that on the Ohio side / in the center of town Mt Adams is probably the safest neighborhood to be. It's well defended being high on a hill and it doesn't blend into other neighborhoods. There's no grocery store that you can walk to on Mt Adams BUT such is the case in many of the best city neighborhoods (Clifton has a small 60's style IGA btw). Mt Adams cab be pricey though.
Immediately north of Eden Park is a good place to rent because you're on the park, but north of Nassau St between Nassau and McMillan becomes kinda dicey and then just flat out ghetto at McMillan (typical Cincinnati: neighborhoods here change drastically within 1-2 blocks).
East Walnut Hills: Cheaper alternative between Mt Adams and Hyde Park / Oakley / Mt Washington. Lotta bikers (Cannondales not Harleys), walkers / runners / dog walkers from EWH and surrounding neighborhoods. Very quiet area, very convenient, beautiful old mansions some of which are chopped up into large apartments. Lotta SFH sized victorian half doubles. There's a newly hip corner at Madison and Woodburn with a coffee joint, tappas restaurant, dry cleaners, etc with brand new apartments built above the place (new construction is rare in this area so I thought I'd mention it...but stay east of Woodburn).
Quick map of the general area:
francis lane, cincinnati oh 45214 - Google Maps
Mt Adams, East Walnut Hills, and some of the areas east / northeast of East Walnut Hills are INCREDIBLY convenient if you wanna be on the Ohio side but need proximity to Kentucky.
* It's a quick jump onto I-471 and a reverse commute at that.
* You have the option of doing your shopping in NKY or Ohio.
* You're minutes from just about everything worthwhile in Cincinnati.
* Your wife can work just about anywhere in Cincinnati.
* The two areas I'm speaking of ARE NOT bland, new build, suburban ticky tacky that Ohio is well known for.
O'Byronville is an often overlooked, trendy little burg between East Walnut Hills and Hyde Park (Madison and Torrence Pkwy). I don't know what the rental stock is like over there but it's definitely worth checking out.
Hyde Park is a lively, 1920's streetcar era suburb. Very yuppie with shops and bistros everywhere. But it's very safe, clean, and it's the furthest thing from boring suburbia.
Oh and there's a ton of cheaper apartments spread out between all the old mansions.