RDU airport is just about
100 miles from Greenville. Roughly an hour and a half drive. It's an easy, fairly straightforward drive, too. Though, if money is not an object, taking flights to the closest airport is always nice. It may be that if you are renting a car already, flying straight into RDU will be the most economical. Check to see what your rates will be once you arrive in Greenville. Your options may be more limited there. Again, if money is no object, rent a limo if one is available. LOL. Else, I'd take the RDU route, rent a car and drive out to Greenville, myself. Just my two cents.