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Old 03-05-2012, 04:29 PM
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I found a previous post about this topic, but it dates to 2009 and is in a thread about Fleas: http://www.city-data.com/forum/9192516-post10.html

Just wanted to post a new warning about these two drugs, when taken together. I didn't know about the interaction and gave Bandit his monthly Ivermectin Thursday night, and also gave him a dose of the flea preventive Comfortis, which we have never used before. Friday morning when we woke, he was obviously overdrugged. The symptoms were: blown pupils, possible sight issues (he bumped into a few things), pronounced lethargy, discoordination. All very concerning, but not necessarily alarming, and so we didn't go to the e-vet. I left a note for the sitter and told her to call me if she saw anything alarming, and her note back to me was that he seemed fine. By the time I got home Friday night, he was pretty much normal.

However, last night I Googled Ivermectin and Comfortis and found that the two drugs taken together can have serious adverse affects and even cause death. I emailed my vet's office and we spoke on the phone today. They were naturally upset that they'd sold me the Comfortis, considering Bandit's history of Ivermectin use, and told me that they'd had an office-wide meeting today to discuss the drug combination, had pulled all the records of their pet-patients on Ivermectin, and had implemented new protocols to ensure this didn't happen for other patients. (This was one of those cases of the front-desk people not knowing that it was a bad combination. Evidently, the inside of Bandit's medical record has the warning, but there's nothing on the outside that might have grabbed the eye of the front-desk staffers.)

So anyway...if you have a dog on Ivermectin -- usually used to treat mange or other mite-related issues -- don't give him Comfortis.
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Old 03-05-2012, 04:44 PM
Location: St. Louis, Missouri
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wow... glad Bandit is ok....

and thanks for the heads up!!
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Old 03-06-2012, 11:57 AM
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For the last couple days Bandit has had diarrhea and vomiting, with diminished appetite and thirst. I took him to the vet this morning. They're thinking that what we're seeing now is a result of the Comfortis, but that the other symptoms from Friday morning were Ivermectin toxicity. The vet told me that Ivermectin metabolizes through the body very quickly and that Bandit shouldn't have any of that left in his system now, after 5 days. I guess it's a different case with the Comfortis. I have a friend who is a vet in Italy, and she said that about 5% of their dogs (who are on Comfortis) react with diarrhea/vomiting. I guess Bandit is just one of the unlucky few. (Or lucky few, depending on your perspective. As I was Googling Ivermectin and Comfortis, I did come across a few accounts of the dogs dying.)

Anyway, they saw me for free and were super apologetic. I stayed home with him today to be on vomit and diarrhea patrol, so now we're just chillin'.
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