Originally Posted by trese
I'd say take I-40--by the way-421 is basically the same thing as 40
Just to clarify, they are not the same thing on the west side of Winston-Salem, or if you're coming down I-77. The two highways merge in Winston-Salem and run together through Greensboro.
There is an ongoing project to bring US 52 up to interstate standards, so it's possible there will be construction delays. If you're planning to come this way, you should check the NC DOT website for status. If backups are indicated, then consider the I-77 to US-421 route I described above.