We have been very happy so far with
Cleveland Park East on NE Main in Simpsonville. Our dog was born with a very serious (and incurable) liver disease and she requires a lot of medical attention. The vets at CPE are competent, caring, and more than willing to seek outside consultations for complicated cases.
The reception area and exam rooms are spotlessly clean and very modern, and they stock every medication and prescription food we've needed. It's kind of out of the way for us, but they came highly recommended, and we have no complaints yet.
I don't know how their fees compare to those elsewhere in the Greenville area, but exam fees are about half of what they were in NY.