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Old 03-30-2011, 07:51 PM
 
Location: Las Flores, Orange County, CA
26,346 posts, read 80,779,498 times
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I was doing a search on an old girlfriend and just found out today that she died in 2006 at age 43. I just spoke with her mother a few minutes ago who told me she had started getting Rheumatoid Arthritis around 1983 (she would have been around 20 then) and it got worse and worse and eventually her heart gave out in 2006 and she died.

Because I didn't want to stress her mother out, I didn't ask more questions.

So now, does anyone have an explanation of what this means? How would Rheumatoid Arthritis lead to a heart attack?
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Old 03-30-2011, 08:05 PM
 
Location: Las Flores, Orange County, CA
26,346 posts, read 80,779,498 times
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Update, I just found this which shows a big time relationship:

Heart attack may risk up to six fold in rheumatoid arthritis | Autoimmune Blog
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Old 03-30-2011, 08:42 PM
 
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I have a 90 yr old gram that has rheumatoid arthritis and has had it for years. I think it may be genetics and what part of the body it is attacking
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Old 03-31-2011, 04:01 PM
 
Location: Newport, Rhode Island
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Rheumatoid arthritis doesn't "cause" heart/blood vessel disease but the breakdown and loss of colligen can cause both.

The material that lubricates the joints is made up of colligen as is the lining of the blood vessels.

When the lining of blood vessels gets stripped away it's called arterial sclerosis or hardening of the arteries.

Both arthritis and arterial scerosis is thought to be caused by high homocystene levels.


http://ard.bmj.com/content/62/7/694.extract
http://www.ncbi.nlm.nih.gov/pubmed/12083806
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Old 04-01-2011, 07:28 AM
 
Location: Durham UK
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It may also have something to do with the Non-steroidal pain killers used in RA.
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Old 04-03-2011, 09:36 PM
 
4,627 posts, read 10,504,468 times
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Quote:
Originally Posted by laidbackhippie View Post
Rheumatoid arthritis doesn't "cause" heart/blood vessel disease but the breakdown and loss of colligen can cause both.

The material that lubricates the joints is made up of colligen as is the lining of the blood vessels.

When the lining of blood vessels gets stripped away it's called arterial sclerosis or hardening of the arteries.

Both arthritis and arterial scerosis is thought to be caused by high homocystene levels.


Reduction in plasma homocysteine level in patients with rheumatoid arthritis given pulsed glucocorticoid treatment -- Lazzerini et al. 62 (7): 694 -- Annals of the Rheumatic Diseases
Upregulation of smooth muscle cell collagen produc... [Mol Genet Metab. 2002] - PubMed result

High homocysteine levels are seen in patients with RA, that doesn't mean high homocysteine levels "cause" RA...

I have never seen such a link even considered.

RA is a systemic autoimmune disease that is chiefly manifested by joint destruction, but there are other manifestations as well including inflammation elsewhere in the body including vessels.
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