New GlaxoSmithKline shingles vaccine gets FDA approval

[suzy_q2010]

Originally Posted by newtovenice

I am aware that incidence and risk are not the same thing.

Risk is based off previous history of incidence. And the population that was used to show incidence, influences the resulting risk statistic.

But not everyone who is at risk will get shingles, correct? And if the risk statistic is based on a population that is 92% immunocompromised --which is not hypothetical as it's right in the study, which was the first of it's kind, btw -- then what is the actual risk of disease (shingles) in healthy adults?

So my question has now changed: Where is the study that calculates the risk factor for healthy adults?

And when will the PI be released?

Annual incidence rates of herpes zoster among an immunocompetent population in the United States:

https://www.ncbi.nlm.nih.gov/pubmed/26546419

By PI do you mean the patient information insert?

http://ca.gsk.com/media/1350788/shin...2017-10-13.pdf

Note that the population studied starts at age 50, so it will not be recommended for use in younger age groups.

[bluedevilz]

Originally Posted by newtovenice

You ae still not understanding the question. My question was what STUDY calculated the risk statistic. Not how risks are identified.

But, just found the study on which the 1 in 3 stat is based by following back cited refs to the original source, which is:

Yawn BP1, Saddier P, Wollan PC, St Sauver JL, Kurland MJ, Sy LS. A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction. Mayo Clin Proc. 2007 Nov;82(11):1341-9.

However: 92% of the adults in the study that creates the 1 in 3 statistic were immunocompromised.

Which means that 1 in 3 immunocompromised adults are at risk.

But what is the risk factor for normal, healthy adults?

No 92% of the adults in the study were NOT immunocompromised

RESULTS:
A total of 1669 adult residents with a confirmed diagnosis of HZ were identified between January 1, 1996, and December 31, 2001. Most (92%) of these patients were immunocompetent and 60% were women

CONCLUSIONS:
Our population-based data suggest that HZ primarily affects immunocompetent adults older than 50 years; 1 in 4 experiences some type of HZ-related complication.


IMMUNOCOMPETENT NOT IMMUNOCOMPROMISED

This IS the risk for "normal, healthy adults" which is what IMMUNOCOMPETENT means....

[in_newengland]

Too many rude posts deleted. Looks like any vaccine threads have to be short.