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Old 03-06-2018, 06:17 PM
 
465 posts, read 195,825 times
Reputation: 1145

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To the people that suggest taking CoQ10 (yet another cost) will alleviate all negative side-effects, what about prenylation?

Here are the things that you are inhibiting, way before HMG-CoA gets made into cholesterol: https://upload.wikimedia.org/wikiped...se_pathway.svg

That's completely ignoring the downstream products of cholesterol, which are both numerous and absolutely vital.

My point is, you're inhibiting a very important pathway high up in the chain, with a million downstream products, in a LARGE segment of an unhealthy population. All based on the poor assumption that high cholesterol is THE CAUSATIVE factor in heart disease. That bothers me, and I can see why some people feel the dire need to inform the uninformed.

Do doctors really check anything else related to the HMG-CoA reductase pathway? Or do they only see high cholesterol and prescribe a generic statin?

And yeah, 15 threads might be overkill XD
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Old 03-06-2018, 08:14 PM
 
14,338 posts, read 18,116,030 times
Reputation: 19344
Quote:
Originally Posted by Travelassie View Post
...It must really irk you to have to upvote another poster to privately send them a snarky comment...

Giving some a rep just to make a snarky comment is against the C-D posting rules. I reported one poster who did that, supposedly anonymously of course, and recommend that you do that too.
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Old 03-07-2018, 08:04 AM
 
16 posts, read 4,073 times
Reputation: 30
Quote:
Originally Posted by lchoro View Post
If you have to take it, take it with COQ10 to offset the side-effects, such as memory loss and muscle weakness/pain (for fall risk). Most cardiologists now recommend the supplement now. Our doctor has been recommending vitamin B complex with Metformin.

https://www.health.harvard.edu/stayi...ent-deficiency

It is too late now as she has been on the medications for 15 years and is almost off the drugs entirely, taking the atorvastatin only due to the high triglyceride and the lowest dosage of metformin for prediabetes level A1c.
It's good that cardiologists are finally starting to get on board with recommending CoQ10 for those on statins. It's so important for doctors to be aware of the nutrients that certain medications can deplete and to guide their patients in supplementing.
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Old 03-07-2018, 08:27 AM
 
Location: Raleigh
6,184 posts, read 4,621,558 times
Reputation: 8181
Quote:
Originally Posted by jaminhealth View Post
My good friend who is very alternative and taught me so much, ended up with afib over a year ago and now the doctors have the stroke fear in her mind. So now she's on a group of heart meds including blood pressure and all t he years I've known her she never had high BP. Maybe one mistake she made was NOT taking enough magnesium for years as this deficiency is so discussed with the afib.

And we know it will never change but just too too bad that MD's won't do more to work with prevention before the drugs have to be given, but I must be a dreamer and my dreams are not about money.
Americans as a rule don't get enough Magnesium. When I was much more dedicated to powerlifting I took ZMA (Zinc and Magnesium) as a supplement. It helped you have a restful sleep, too. I looked into why, and it seems like its just the soil on our continent.
Quote:
Originally Posted by jaminhealth View Post
This subject is absolutely maddening in today's modern world and for sure here in the U.S. I would not take them and I don't have a fear of cholesterol for starters. There are SO MANY schools of thought and papers, articles on this subject. All I can say FOR SURE is my parents generation did NOT take statins, they didn't exist, and I don't know of alzheimers in these people I knew. My folks lived into 90's, ate every thing in their lives and had their minds at their ends.

https://www.healthline.com/health/hi...nd-memory-loss

I don't even know if this generation had all the labwork that is done today. Something tells me NO.
...And I know plenty that outlived their parents by 20+ years.
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Old 03-07-2018, 10:07 AM
 
Location: Santa Monica, CA
15,225 posts, read 4,785,147 times
Reputation: 10500
JONOV: Good mag comments, I started questioning this mineral years ago as there is such a push for calcium and then I started to read and read and found so much on the mag deficiency. Thanks.
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Old 03-07-2018, 10:24 AM
 
2,278 posts, read 5,875,222 times
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My mother died of strep in 1935,temp 106,was treated with 16 blood transfusions,I was 2 years old.
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Old 03-07-2018, 10:49 AM
 
Location: Santa Monica, CA
15,225 posts, read 4,785,147 times
Reputation: 10500
Quote:
Originally Posted by Haksel257 View Post
To the people that suggest taking CoQ10 (yet another cost) will alleviate all negative side-effects, what about prenylation?

Here are the things that you are inhibiting, way before HMG-CoA gets made into cholesterol: https://upload.wikimedia.org/wikiped...se_pathway.svg

That's completely ignoring the downstream products of cholesterol, which are both numerous and absolutely vital.

My point is, you're inhibiting a very important pathway high up in the chain, with a million downstream products, in a LARGE segment of an unhealthy population. All based on the poor assumption that high cholesterol is THE CAUSATIVE factor in heart disease. That bothers me, and I can see why some people feel the dire need to inform the uninformed.

Do doctors really check anything else related to the HMG-CoA reductase pathway? Or do they only see high cholesterol and prescribe a generic statin?

And yeah, 15 threads might be overkill XD
All this chemistry is way over my head but is it basically saying how important cholesterol is. I've been taking COQ10 as part of my heart health regime for some time. Is it not necessary? Thanks.
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Old 03-07-2018, 10:57 AM
 
Location: Woodstock, GA
1,920 posts, read 3,249,041 times
Reputation: 2086
Quote:
Originally Posted by jaminhealth View Post
This subject is absolutely maddening in today's modern world and for sure here in the U.S. I would not take them and I don't have a fear of cholesterol for starters. There are SO MANY schools of thought and papers, articles on this subject. All I can say FOR SURE is my parents generation did NOT take statins, they didn't exist, and I don't know of alzheimers in these people I knew. My folks lived into 90's, ate every thing in their lives and had their minds at their ends.
I know for sure that none of my grandparents were ever diagnosed with Alzheimers. Because back then they didn't call it that: they just called it "senility". Today we know that it was really Alzheimers. My grandfather suffered from "senility" for many years before he died. It was common even back then, but was never diagnosed as Alzheimers unless the patient was under 65.
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Old 03-07-2018, 11:02 AM
 
Location: Santa Monica, CA
15,225 posts, read 4,785,147 times
Reputation: 10500
Quote:
Originally Posted by billl View Post
I know for sure that none of my grandparents were ever diagnosed with Alzheimers. Because back then they didn't call it that: they just called it "senility". Today we know that it was really Alzheimers. My grandfather suffered from "senility" for many years before he died. It was common even back then, but was never diagnosed as Alzheimers unless the patient was under 65.
Hear you. I've posted info in Alt Med on supps to prevent/reduce this "senility" issue. I'm 80 soon and thank goodness mind is good.
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Old 03-07-2018, 11:37 AM
 
1,025 posts, read 379,543 times
Reputation: 1830
The best way to fight dementia of the aging variety (Alzheimer's and other types of dementia may be hereditary) is by exercising the body and the mind. Be careful of supplements because if we eat right we really don't need them unless we have a deficiency like Vitamin B12. Overtaking certain supplements can cause more harm than good and some supplements interact badly with medications you may be on.
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