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Old Today, 10:58 AM
 
24,345 posts, read 17,950,766 times
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can't wait to see some human trials results.

New Compound Shows Promise in Treatment of Alzheimer’s

paper here

Quote:
Yale researchers have identified a drinkable cocktail of designer molecules that interferes with a crucial first step of Alzheimer’s and even restores memories in mice,*they report Jan. 2 in the journal Cell Reports.
The binding of amyloid beta peptides to prion proteins triggers a cascade of devasting events in the progression of Alzheimer’s—accumulation of plaques, a destructive immune system response, and damage to synapses.

Strittmatter and research scientist*Erik Gunther*screened tens of thousands of compounds looking for molecules that might interfere with the damaging prion protein interaction with amyloid beta. They found that an old antibiotic looked like a promising candidate but was only active after decomposing to form a polymer. Related small polymers retained the benefit and also managed to pass through the blood-brain barrier.
They then dissolved the optimized polymeric compound and fed it to mice engineered to have a condition that mimics Alzheimer’s. They found that synapses in the brains were repaired and mice recovered lost memory.
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Old Today, 03:28 PM
 
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Lots of things work in mice but not people. There's an old drug called clioquinol that gets rid of plaques in mice, but the tests in people were not conclusive.



https://www.newscientist.com/article...e-brain-cells/
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Old Today, 08:37 PM
 
Location: Southern California
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There are supplements right now that reduce amyloid plaque, I take one for many yrs.
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Old Today, 08:46 PM
 
Location: Central IL
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Originally Posted by jaminhealth View Post
There are supplements right now that reduce amyloid plaque, I take one for many yrs.
Share, share!
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Old Today, 09:46 PM
 
91 posts, read 15,423 times
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Quote:
Originally Posted by jaminhealth View Post
There are supplements right now that reduce amyloid plaque, I take one for many yrs.
I have not heard that. Inflammation plays a part in Alzheimer's so anti-inflammatories may help. I take turmeric and fish oil.

Here's a good article:
https://www.gmjournal.co.uk/can-diet...disease-part-1
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Old Today, 10:13 PM
 
Location: Southern California
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Originally Posted by reneeh63 View Post
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If it's good enough for Mice, why not Man?

https://link.springer.com/article/10...640-009-9000-x

There are many more links to read also on this Grape and the brain.
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Old Today, 10:49 PM
 
91 posts, read 15,423 times
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Quote:
Originally Posted by jaminhealth View Post
If it's good enough for Mice, why not Man?

https://link.springer.com/article/10...640-009-9000-x

There are many more links to read also on this Grape and the brain.
https://www.npr.org/sections/health-...ried-in-people
Quote:
Rats and humans have been on their own evolutionary paths for tens of millions of years. We've developed our own unique features, and so have the rodents.
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