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Old Yesterday, 12:39 AM
 
4,983 posts, read 3,118,017 times
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Quote:
Originally Posted by Bayarea4 View Post

I have been checking out Inositol and am looking forward to trying it. Our local GNC carries it, but it's $150 for what looks like about a gallon size jar, so I gave it a pass and will look for another source.
I have a bottle of Inositol capsules that costs just $10 or $12 from Amazon.com.

What are you referring to?
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Old Yesterday, 09:43 AM
 
301 posts, read 663,282 times
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Default re: trazadone

Quote:
Originally Posted by Willamette City View Post
I have primary insomnia. I'm a 65 year old male. I take various supplements and prescribed medications to get usually 5 to 6 hours of sleep a night. All medications have side effects and one medications side effect has screwed my body up quite a bit. The medication as noted in the title is Trazodone. Trazodone is an antidepressant, but prescribed for insomnia. I noticed several months ago that one side effect of Trazodone is inability to ejaculate. I realize this a cringe worth topic.
But the Pacific Standard Time right now is 4:11 am. I've been up since 3 am. On doctors orders I decided to go off Trazodone cold turkey. My question to any that are up at this hour is: have you had any similar effects from this medication. If so, what did you do about it?


Any and all comments are appreciated.
Hi- late 40's male, here. I'm on trazadone for the same thing (sleep aid) and have noticed that, though I'm scribed 1 1/2 pills before bed for sleep, over a few years I've crawled up to sometimes taking 2 in order to get the same effect. Not sure if it's added stresses of life over that time, or if my body needs More now than it did years back in order to get the same effect. trazadone does not affect my ability to ejaculate. It sometimes might lengthen time To ejaculation though. though I'm on two other meds, so could be polypharmacy at work --- interaction between the three meds.???? causing longer time to.... PS- I had a single script of clomazepam a couple years ago and one pill of those was awesome for sleep. but my doctor said it'd be bad for my body to use it chronically for that purpose. oh well.
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Old Yesterday, 10:47 AM
 
214 posts, read 102,324 times
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Some observations in Trazodone (AKA Desyrel), from an occasional user and prescriber.

1) It is an older antidepressant that, at lower doses (0-300), is commonly used as a sleep medication. This is taking advantage of a major side effect: sedation.
2) At higher doses (400-600), it exerts antidepressant effect.
3) It largely fell into disuse as an antidepressant because of the rise and and preponderance of SSRI = selective serotonin reuptake inhibitors -- medications such as Prozac, Paxil, Celexa, Lexapro, Zoloft.
4) I still prescribe it (in psychiatry) as a sleep medication.
5) To see if it will work in you -- the patient, you have to follow instructions and run a "controlled" experiment.
6) Why? Because a) no one medication will work for everybody (but that doesn't mean it is useless); and 2) it may work at a certain dose (to be determined); however, if you overdose it or overdose it, it wouldn't work right.

7) Three main variables in sleep medication: a) in general, what's going on around you/environment; b) how much medication you take; c) what time of night you take the medication.

a) I'm not going to spend lots on environment. This is called "sleep hygiene" -- creating conditions that are conducive to getting a good sleep. Stuff like temperature (cool), light (dark), and avoiding substances (caffeine) or activities (too vigorous exercise right before bed) that are not conducive to sleep.

My focus in my instructions (to my patients is controlling b) and c).
Rule: ***if you take too much medication, too late in the evening, you will get grogginess the next morning. If you take the right amount of medication too late at night, same result. If you take too much medication at the right time in the evening, same result.

Therefore: take the right amount of medication at the right time in the evening, and then (and only then) you have a "controlled" experiment to see whether Trazodone will work for you.

Let's apply this. Let's say you want to go to sleep about 10pm. Take the sleep medication around 9 to 9:30pm or so. To control that variable during the experiment, take the medication at the same "reasonable" time every evening. Don't take it at 8pm one night, 11pm, another night. etc.

But how much medication should I take? If Trazodone's range for sleep is 0-300, how do I know whether I need 25mg or 300?

The three most important words to remember are these: TITRATE TO EFFECT. How? Start low, and go slow.
I normally prescribe Trazodone 50mg, take 1-3 tabs orally at night.

You can cut a 50mg pill in half and have 25mg increments. Start low, go slow. The first night, you can take 25, or even 50, both of which are lower doses. What happens? If it takes you two hours to go to sleep, or if you fall asleep but wake up five hours later, in either circumstance you need to increase the dose the next night. Make sense?

Titrate to effect means that you gradually increase the dose, night after night, until -- hopefully -- you find a "sweet spot". The sweet spot is the number of hours of sleep you require. That spot is usually anywhere between 25 to 300.

Advantages of Trazodone as a sleep medication:
1) it is dirt cheap. Really. You will not go broke.
2) It is not a controlled substance (non-controlled substances have less risk than controlled substances).
3) No weight gain (to the best of my knowledge).
4) In a psychiatry book, years ago I read that it actually improves "sleep architecture."

Disadvantages of Trazodone as a sleep medication:
1) Side effects: I'm not going to list every side effect -- the list is too lengthy. It is suffice to say every medication has side effects. Deal with it. If you can't deal with it, then don't take medications.
We can distinguish mild-moderate side effects from more serious side effects.

In this thread, several individuals -- males? -- have mentioned sexual side effects. I haven't heard that complaint consistently regarding Trazodone, but since Trazodone directly effects serotonin levels, it surely could cause anorgasmia (= inability to ejaculate). I do not think that Trazodone causes erectile dysfunction. These are two distinct side effects.

In 1 in 10,000 cases, Trazodone can cause priapism in males. If that happens, and you have "x" for more than four hours, this is a serious side effect and you need to go to the ER. I have never seen it in clinical practice, but it can happen. This is, of course, not a problem in females, so I think Trazodone is an great choice for females with insomnia.

I occasionally will have patients complain of vivid dreams. Some stay on it; others discontinue it.

Is this sleep medication for everybody? No. Will it work in your? I don't know -- you must run your own controlled experiment.

Please check with your primary care provider, general provider, internist, or psychiatrist whether this medication may be appropriate to try for your sleep problems.

Last edited by townshend; Yesterday at 11:13 AM..
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Old Yesterday, 11:16 AM
 
Location: Wine Country
5,063 posts, read 6,120,212 times
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Quote:
Originally Posted by matisse12 View Post
Amitriptyline is an alternative to Trazadone. Both are old-fashioned out-of-date anti-depressants which are no longer used for depression, but are prescribed for insomnia instead.

I did not like the side effects of Trazadone after trying it for a short period - it made me have a chemicalized feeling. Amitriptyline, though, suits me fine and is effective.

You could try Amitriptyline which is often prescribed for insomnia, and also take L-Tryptophan tablets and perhaps over the counter Alteril which contains L-Tryptophan, Melatonin, and similar ingredients. I've recently added these two to my Amitriptyline routine.

I do think Amitriptyline might subdue ability to orgasm (subdue a little but not prevent it), but you could try it.

I don't believe in taking prescription sleeping pills such as Ambien or Lunesta - too many side effects plus becoming addicted plus Ambien can easily cause sleepwalking and even getting up and driving one's car while sleepwalking and not even remembering it.
I am on amitriptyline for Peripheral Neuropathy. When I was first taking it I had some side effects that were mainly fatigue and feeling spacey. But as I have been acclimated to it the only thing it does is contribute to constipation. It no longer makes me sleepy, but with a combination of medications I have been able to relieve my PN and for me that is huge.

I have struggled with insomnia for the past 7 years on and off. I have done everything under the sun to get a good night sleep. Without the help of either a very small dose of Ambien or a little bit of marijuana I am not going to get a full night's sleep.
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Old Yesterday, 04:13 PM
 
Location: NJ
9,777 posts, read 20,678,012 times
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Quote:
Originally Posted by Willamette City View Post
Thank you Mikala43. Yes let's get back on topic. I practice good sleep hygiene and have for years. We have a fan going at night, the bedroom is kept at 55 to 60 F. I don't have sleep Apnea, so that is not an issue. My wife and I put a twin and queen bed together so we have a large area to sleep in. I can roll over constantly and it doesn't bother her. We also have a spare bedroom that I can go to if need be.


I've been working with a sleep specialist since the early 90's.


I start working on my sleep medication at about 9:30 pm, so by 10 to 10:30 I'm ready for bed. I generally fall asleep quickly. The problem is I usually wake up between 1:00 to 2:00 am. In the past, I would take some Tryptophan, Valerian root and Melotonin. That did the trick to get another 2 to 3 hours of sleep. I try to get off the computer by 9 pm. I pretty much wind down for an hour or so and am pretty sleepy by 10. This regimen usually works pretty well.


When I read the side effects of Trazodone, the bells went off. My problem is rare, but is listed as a side effect of Trazodone. The problem I'm having now is a rebound effect from stopping Trazodone to soon. I should have tapered and will start that now.


I've also tried meditation with no positive results. Understand this: I've had sleep issues since I was 9 years old. I take after my mother, who had sleep issues all her life. I was diagnosed as a Primary insomniac in the mid 80's. The mistake was going cold turkey. Not a good idea.


Thanks for all the input! I'll keep you posted on the results.
Have you ever tried the OTC midnite to get back to sleep? If not I suggest trying it. As for a sleeping pill, I do generic lunesta 3mg but you'd only need 2mg. It's the only pills that works for my daughter and I. I have all sorts of med allergies but have no issues with lunesta. If my insurance charges me $50 I can get with goof RX for $22 at CVS
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Old Yesterday, 06:05 PM
 
Location: San Francisco
16,066 posts, read 5,113,472 times
Reputation: 49398
Quote:
Originally Posted by matisse12 View Post
I have a bottle of Inositol capsules that costs just $10 or $12 from Amazon.com.

What are you referring to?
I am referring to a product GNC sells that is in powder form and comes in a large tub. I passed on that, but this afternoon I found a bottle of 500 mg. Inositol capsules at our local health food store for about $15.
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Old Today, 11:55 AM
 
8,439 posts, read 5,760,086 times
Reputation: 15762
Any human can react in any way to any substance, that said, failure to ejaculate is not a listed side effect. Lack of libido and ejaculation disorder (non-specific) is <1-2% and

Isn't it easier to just look up a medical site like Medscape.com or drugs.com?

https://www.drugs.com/cons/trazodone-oral.html

https://reference.medscape.com/drug/...one-d-342965#4
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Old Today, 04:00 PM
 
4,983 posts, read 3,118,017 times
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Quote:
Originally Posted by mike1003 View Post

Any human can react in any way to any substance, that said, failure to ejaculate is not a listed side effect. Lack of libido and ejaculation disorder (non-specific) is <1-2% and

Isn't it easier to just look up a medical site like Medscape.com or drugs.com?

https://www.drugs.com/cons/trazodone-oral.html

https://reference.medscape.com/drug/...one-d-342965#4
Amitriptyline makes it more difficult to get to orgasm for some people, as does Zoloft (Sertraline) for some people.

Difficulty in getting to orgasm is different from complete failure to orgasm.

I'm referring to females with Amitriptyline, and to males with Zoloft. (but both genders apply)

It can be stated that difficulty in getting to ejaculating (rather than failure to ejaculate) is experienced by some males on Zoloft (an anti-depressant). There is a difference between having some difficulty getting to orgasm and complete failure to ejaculate/orgasm.

Last edited by matisse12; Today at 04:41 PM..
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