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Well i just read this article on my science magazine MIT Technology Review about how scientists at 3 different research centers in the USA have given the antifungal drug Rapamycin to old mammals and extended their life span in these experiments. Before this the only way to extend the lifespan in mammals has been by either genetic engineering or calorie restruction.
The fact that it HAPPENS to be an antifungal drug (one which is EXTREMELY toxic to people) has nothing to do with this action. It's the receptor for the drug that's the important thing.
Chlorine bleach is a wonderful antifungal agent, but I don't think it's something that would be helpful in extending life.
Yeap they did say that they're unsure how it works as possibly it effects the same longevity genes or enzymes (Sirtuins) that calorie restriction does but again who knows as they'll need more research for sure .
The fact that it HAPPENS to be an antifungal drug (one which is EXTREMELY toxic to people) has nothing to do with this action. It's the receptor for the drug that's the important thing.
Chlorine bleach is a wonderful antifungal agent, but I don't think it's something that would be helpful in extending life.
So you are suggesting that chlorine bleach can be used by humans to treat a fungal infection?
Of course not. I'm just pointing out the absurdity of some peoples' assumptions.
BTW, the other name for rapamycin is sirolimus. We use this drug for immunosuppression in bone marrow transplant and solid organ transplant patients so that they don't reject the graft.
Every drug has both good and bad unintended consequences. Some more dramatic than others.
Cyanide is said to be the only drug with a single outcome.
Commonly prescribed blood thinners are often used to kill vermin.
Morphine given in rats causes a 'stovepipe rigidity' where the animals can almost be posed to hold a posture. Morphine given to mice intensively increases their activity.
Work had been done on a chrolinated sugar that was believed to have male contraceptive activity. Turned out to be marketed as an artificial sweetener.
Careful review of clinical study data in a large enough population or in the post marketing phase may reveal subtlities not seen or predicted. It is here where those isolated information begins to show a pattern. You then may see new saftey concerns or unintended benefits. It is a grab bag of gold and chunks of coal.
During drug discovery, new chemical entities may be run through a series of mice as part of preclinical screening to establish a profile which is then compared to standard drugs. If the new chemical is injected into a leg and causes the limb to go limp, the drug may have a local anesthetic properties and be directed toward cardiovascular investigation.
Often a new chemical compound displays a strong profile that directs further investigation to a specific therapeutic area. It is, however, in the company's best interest to not file for new drug approval unless all indications are thoroughly studied. Approval for marketing a new drug is limited to the specific indications studied and filed for. Any new uses for an approved drug may have a 'use patent' filed by a competitor.
Longevity may be a perceived benefit that carries along with it, an undesirable companion effect.
Does it remove a threat from a particular pathology or does a given pathology trump the longevity the drug provides?
Does it raise overall immunity?
Is there a specific population or precondition that allows it to increase longevity?
will it be restricted to veterinary use?
To take advantage of the drug do you need to eat healthy and exercise and be genetically lucky?
Lot of research to be done. Raises company stock price at least for a brief spike.
I will probably get hit by a bus because I'm too preocupied by making sure I'm taking the right vitamin.
That's hiliarious, Just-Sayin. Me, too.
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drug discovery is still serendipitious
