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I'll say that I've gotten very nice hotel rooms in Des Moines for around $45 through name your own price places (priceline, orbitz, expedia, etc). I'd try something like that. Pretty much anything downtown (except the crackhead extended stay hotels, but they're not on these sites) or in the suburbs will be nice.
Like most places, I think anything you find just randomly alongside the road or in smaller cities might be kind of dodgy. I'd definitely try to hit up Des Moines, Iowa City, Quad Cities or the Omaha/Counciltucky area. I assume you'll be on I-80? If you'll be on I-35, Des Moines or Ames is your best bet.
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