Route 22 is the highway through the heart of the valley. It is at many times a nightmare, with traffic back-ups, accidents, and many areas of design which are completely obsolete. However, it is advertised in the real estate listings because commuters who work outside the area generally want to live in close proximity to either Route 22 or Interstate 78 in the Valley. It also runs right next to the Lehigh Valley Mall.
Here is the website about Route 22:
Route 22, Section 400 in the Lehigh Valley
And the Wiki (the part you are talking about is the Lehigh Valley Thruway):
U.S. Route 22 in Pennsylvania - Wikipedia, the free encyclopedia