Well, let's see now.... First is the well known (in Louisiana anyway) people difference. North La was settled by southerners from the SE and Appl. mts. Mostly non Catholic. There is less wealth up here as a whole. Probably more poor AA's as a whole. NLa is mostly rural with only a few cities and seems to like it that way
The topography is a little more rolling hill/less swamp. But there is still plenty of swamp and bayous even up north here. A few degrees hotter in the summer and likewise colder in the winter, less rain as a rule, more snow and ice esp around Shreveport.
Up here there are no good examples of French Cajun culture. Natchitoches is an old French settled town with many descendants still around the area. It is not Cajun French, rather it was an outpost in the Lousiana territory. Predates the Cajun arrival by a few years.
South Louisiana has more wealth and prosperity, more different kinds of cultures, lots of fun festivals, not so rednecky, and Catholic. The people are interesting to me and are involved in all kinds of activities.
BTW, I am originally from north La although I have lived in both areas.