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Bus is ok, first clases buses are good. It should take about 4 hours (tops)
It is a beautiful drive that is well worth. Guandalajara-Sayula-Cd Guzman-Colima-Cuyutlan-Manzanillo. You have to stop in Colima and take (rest) a very good look at the Volcanoes... About 3 hours (tops). Highway all the way.