I don't care for Mississippi but I am familiar with these areas. Grew up in O.S. and have family all over MS Gulf Coast. The reason I don't like MS Gulf Coast is the lack of control over housing built around you. You can build a wonderful great-looking house and someone with terrible taste can erect who knows what! And then 5 more people like that build around you!
I would try to live in
Ocean Springs if I were you. It tends to be pricier than the other areas. Schools are definitely good there. I'm never embarrassed to say I graduated from there. Class of 87!

I had a really nice life there growing up. Sometimes I wonder why I don't want to go back and stop paying all this money for private schools,but I don't. Be very careful with builders; half don't know what they are doing and do shoddy work.
We did live in Vancleave at the beginning of our young married lives. Now looking back, I don't see how I lived there. Well, I do know... we couldn't afford Ocean Springs! It's(Vancleave) supposedly an up and coming place. It is very country and that's just not me. I lived there to please my husband and was forced to have pigs, chickens!

Finally, he came to his senses and made me move to Mobile.

Anyway, many have moved there from Pascagoula and Gautier, some even from Ocean Springs. There is a nice area to live : the bayou part. Otherwise, it's acreage. My grandparents had a summer fish camp there and it was a magical place. Some parts flood.
There is also the
Diamondhead golf resort area right on I-10, north of Bay St. Louis. My in laws live there and I know there is land available to build on.
Woolmarket used to be a bad area, but it isn't anymore. My brother lives in that area on Dogwood Golf Course and there are many nice houses on the way to this golf course. It seems to be a great location, midway. I don't know about their schools because she sends hers to Ocean Springs.
I wouldn't drive back and forth on I-10 from Alabama because the traffic is really bad. Noone will get out of the left lane so you can pass. And with gas the way it is, you need to be thinking closer to work.