Having worked and spent time in Clarksdale I can tell you it is a very economically depressed area. I also have friends who live in Clarksdale who say gunshots are a common sound at night, and regardless of the neighborhood you live in you are at risk. These same friends have learned to chain belongings in their lawns so they don't get stolen.
In 2001 the reported incidents of crime were nearly double that of the national average. While this has improved, crime in Clarksdale is still well above the national average.
http://www.city-data.com/city/Clarks...ssissippi.html