The World, the Flesh and the Devil. 1959, Harry Belafonte. Miner Ralph Burton (Belafonte) is trapped in a mine for a few days (I'm not sure of the exact time). When he emerges, he finds the world has been completely depopulated (not even any corpses) and he is the only one left. This is one of those films I will always stop to watch when it's on (which is VERY rarely), since I can't find it on DVD or even on tape.
The Omega Man (1971) and
28 Days Later (2002) have both done variations of the theme (I'm sure there are others as well) but I feel
The World, the Flesh and the Devil did it better than any other. Too bad not many people are familiar with
TWtFatD and think
28 Days Later is a totally original story. Don't get me wrong, I loved that movie and felt it was particularly well done, but it wasn't the first

.
Would I love to get a copy of that flick!