Bend...
If you like 'dry - arid', more remote (2.5 + hrs to Int'l airport), medium size city with outward growth (sprawl), Higher edu, and a bit more culture availability (concerts, arts, theatre). Close to 'open area' hiking / recreation, dry area events; motorcycles, horses, ranches, farming. Much more 'yuppie' control on city / social. Some serious social structure, as many of the originals have been 'chased-out'. (and those remaining are none too happy) Lots of Californians and the culture they bring (cars / attitude

). Recreation is mtn based, and some rafting / lake spots
Hood River, - more rain / moisture / clouds
climate is transitional... near 'rain forest' 20 miles to the west (High undergrowth and 70+" rain / yr). High desert to the east ~ 20 miles- Closer to Portland / airport / culture (1hr) -
restricted growth (constricted physical area... valley surrounded by CGNSA / National forest / river)
small trendy area (shops) and folks have learned to 'live-together', tho painful for locals; they still are allowed a 'presence' in community and gov. The transplants seem more tolerant of the existing culture, and I don't see it 'transforming' as has happened to Bend.
Recreation varied - Mtn, Water, (wind surf/sail) + fishing, Kayak, and rafting (20 min north on Klickatat or White Salmon rivers), Gorge Hiking, (very scenic comparatively, but different)
Need to try them on, and really look to what you want (socially). HR might be too 'slow' if 'social excitement' is a high need. If you can be happy finding / doing your own recreation, and driving to Portland when you need a 'social hit'... HR would work. (jobs will be tough to find in HR)
I hope the gorge can continue to support locals and transplants...
good luck, your mileage may vary