There is a poster on here
lialleycat who has sought very similar info - so if you search on her threads you will find a lot of opinions.
Septic tank regulations are much stricter in PA than they have been in NY. A place that burned and can be rebuilt upon less than a year after the fire will go through approvals a lot faster than the equivalent raw land.
Here's a few thoughts:
Susquehanna County - seems so far to have escaped the sprawl engine. Many beautiful stone walls - flagstone still is quarried for regional sale there. If you stay relatively close to I-81 you might have hope to stay within your commute/shopping radii of Binghamton or Scranton. Center realtor searches on New Milford and adjacent. (NOT Milford, New Milford.

)
Bloomsburg area - search threads on here, some shopping including Tractor Supply, or head to Wilkes-Barre or Sunbury. Jobs, maybe a few local but otherwise Hazleton or WB. Realtor search on Bloomsburg out 20 mi.
Upper Dauphin County, lapping over into southern Northumberland and far western Schuylkill - Harrisburg would be source of jobs and most shopping but Elizabethville has a super Wal-Mart now and is rumored to be getting Tractor Supply. Sunbury area is alternate for shopping (actually across the river in Hummels Wharf and Shamokin Dam but referred to as "Selinsgrove" too

) Check auction links from
Sentinelnow.com - The Upper Dauphin Sentinel Online , and realtor links on Elizabethville out 20 miles.
Perry County - Still has no traffic light, still located in the federally defined Appalachian Region, but more and more on the cusp of sprawl. Jobs in Harrisburg or maybe State College, shopping in Harrisburg or small strip in Newport, large strip mall in mid-approvals coming to the Newport exit from US 22/322. Local newspapers:
About Us and realtor links from Newport out 15-20 miles.