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I agree with Chet - unless you've spent the money already, you can't be 100% certain. Underwithholding can cost you interest and a penalty.
Also, the 7.5% is off your AGI (Adjusted Gross Income), so if you have any interest or other incidental income, that'll be added to your W-2 income. There are other adjustments as well, so unless you're very familiar with tax returns, I wouldn't mess with the deductions for now. Once you've paid all the medical expenses you expect to pay, you can then lower your withholding for the remainder of the year by filling out another W-4 with your employer.
Not wanting to wait till next year for the tax refund makes sense - but only if you have facts, not estimates... JMHO
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