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It matters kind of hugely where on 45th Street you are. Are you near the Children's Hospital or closer to Butler?
If you're close to Butler, that could be a little bit of a hike. If you're close to the Children's Hospital, you can take the 54C from the corner of Penn & Main closest to the Sunoco all the way to Pitt, very easily. There is definitely not a subway in the East End or really in Pittsburgh generally as a whole (yes, I do know about the Downtown "subway," but come on).
Also, I wait at that intersection each morning during Rush Hour and have never seen a full 54C at that time. It's pretty unlikely that the bus is going to fill with people from the North Side and Strip District before getting to Lawrenceville. I would be more worried if you lived in Bloomfield.
In any case, I live between 42nd and 44th. Welcome to the neighborhood.
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