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Old 11-09-2021, 05:52 PM
 
5,517 posts, read 2,402,623 times
Reputation: 2159

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Not surprising given Dr. Kory had an Ivermectin paper also retracted last year due to unsubstantiated claims.

The key FLCCC paper on their main protocol has been retracted after understating the true number of deaths in the treatment group by ~78%

From the hospital where this work was conducted:

"...a careful review of our data for patients with COVID-19...only 25 of 191 patients (13.1%) received all 4 MATH+ therapies, and their mortality rate was 28%" rather than 6.1% cited in the article

The MATH+ protocol in the now retracted paper involves methylprednisolon, anticoagulant, vitamins B, C, and D, zinc, and melatonin before sleeping.
Remember that the hospital confirmed that more patients died under the MATH+ protocol than other patients in the same hospital.

Of note, the last author (the only one associated with the hospital) was reprimanded for prescribing drugs to people who were not his patients. He also has 2 papers marked for plagiarism on PubPeer (1 retracted).

https://journals.sagepub.com/doi/pdf...85066620973585

https://retractionwatch.com/2021/11/...flawed-results
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Old 11-09-2021, 08:28 PM
 
19,014 posts, read 27,562,983 times
Reputation: 20264
The evidence base for ivermectin against COVID-19

To date, the efficacy of ivermectin in COVID-19 has been supported by the following:
  1. Since 2012, multiple in vitro studies have demonstrated that Ivermectin inhibits the replication of many viruses, including influenza, Zika, Dengue, and others.917
  2. Ivermectin inhibits SARS-CoV-2 replication and binding to host tissue through several observed and proposed mechanisms.18
  3. Ivermectin has potent anti-inflammatory properties with in vitro data demonstrating profound inhibition of both cytokine production and transcription of nuclear factor-κB (NF-κB), the most potent mediator of inflammation.3739
  4. Ivermectin significantly diminishes viral load and protects against organ damage in multiple animal models when infected with SARS-CoV-2 or similar coronaviruses.31,32
  5. Ivermectin prevents transmission and development of COVID-19 disease in those exposed to infected patients.4045
  6. Ivermectin hastens recovery and prevents deterioration in patients with mild to moderate disease treated early after symptoms.45,4952,61,62
  7. Ivermectin hastens recovery and avoidance of ICU admission and death in hospitalized patients.45,51,53,6366
  8. Ivermectin reduces mortality in critically ill patients with COVID-19.45,53,63
  9. Ivermectin leads to temporally associated reductions in case fatality rates in regions after ivermectin distribution campaigns.48
  10. The safety, availability, and cost of ivermectin are nearly unparalleled given its low incidence of important drug interactions along with only mild and rare side effects observed in almost 40 years of use and billions of doses administered.75
  11. The World Health Organization has long included ivermectin on its “List of Essential Medicines.”
A summary of the statistically significant results from the above controlled trials are as follows:
Controlled trials in the prophylaxis of COVID-19 (8 studies)
  1. All 8 available controlled trial results show statistically significant reductions in transmission.
  2. Three RCTs with large statistically significant reductions in transmission rates, N = 774 patients.4446
  3. Five OCTs with large statistically significant reductions in transmission rates, N = 2052 patients.4043,47
Controlled trials in the treatment of COVID-19 (19 studies)
  1. Five RCTs with statistically significant impacts in time to recovery or hospital length of stay.45,49,53,64,65
  2. One RCT with a near statistically significant decrease in time to recovery, P = 0.07, N = 130.54
  3. One RCT with a large, statistically significant reduction in the rate of deterioration or hospitalization, N = 363.49
  4. Two RCTs with a statistically significant decrease in viral load, days of anosmia, and cough, N = 85.57,60
  5. Three RCTs with large, statistically significant reductions in mortality (N = 695).45,60,65
  6. One RCT with a near statistically significant reduction in mortality, P = 0.052 (N = 140).53
  7. Three OCTs with large, statistically significant reductions in mortality (N = 1688).51,63,66
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Old 11-09-2021, 09:37 PM
 
4,160 posts, read 4,872,068 times
Reputation: 3909
Quote:
Originally Posted by ukrkoz View Post
The evidence base for ivermectin against COVID-19

To date, the efficacy of ivermectin in COVID-19 has been supported by the following:
  1. Since 2012, multiple in vitro studies have demonstrated that Ivermectin inhibits the replication of many viruses, including influenza, Zika, Dengue, and others.917
  2. Ivermectin inhibits SARS-CoV-2 replication and binding to host tissue through several observed and proposed mechanisms.18
  3. Ivermectin has potent anti-inflammatory properties with in vitro data demonstrating profound inhibition of both cytokine production and transcription of nuclear factor-κB (NF-κB), the most potent mediator of inflammation.3739
  4. Ivermectin significantly diminishes viral load and protects against organ damage in multiple animal models when infected with SARS-CoV-2 or similar coronaviruses.31,32
  5. Ivermectin prevents transmission and development of COVID-19 disease in those exposed to infected patients.4045
  6. Ivermectin hastens recovery and prevents deterioration in patients with mild to moderate disease treated early after symptoms.45,4952,61,62
  7. Ivermectin hastens recovery and avoidance of ICU admission and death in hospitalized patients.45,51,53,6366
  8. Ivermectin reduces mortality in critically ill patients with COVID-19.45,53,63
  9. Ivermectin leads to temporally associated reductions in case fatality rates in regions after ivermectin distribution campaigns.48
  10. The safety, availability, and cost of ivermectin are nearly unparalleled given its low incidence of important drug interactions along with only mild and rare side effects observed in almost 40 years of use and billions of doses administered.75
  11. The World Health Organization has long included ivermectin on its “List of Essential Medicines.”
A summary of the statistically significant results from the above controlled trials are as follows:
Controlled trials in the prophylaxis of COVID-19 (8 studies)
  1. All 8 available controlled trial results show statistically significant reductions in transmission.
  2. Three RCTs with large statistically significant reductions in transmission rates, N = 774 patients.4446
  3. Five OCTs with large statistically significant reductions in transmission rates, N = 2052 patients.4043,47
Controlled trials in the treatment of COVID-19 (19 studies)
  1. Five RCTs with statistically significant impacts in time to recovery or hospital length of stay.45,49,53,64,65
  2. One RCT with a near statistically significant decrease in time to recovery, P = 0.07, N = 130.54
  3. One RCT with a large, statistically significant reduction in the rate of deterioration or hospitalization, N = 363.49
  4. Two RCTs with a statistically significant decrease in viral load, days of anosmia, and cough, N = 85.57,60
  5. Three RCTs with large, statistically significant reductions in mortality (N = 695).45,60,65
  6. One RCT with a near statistically significant reduction in mortality, P = 0.052 (N = 140).53
  7. Three OCTs with large, statistically significant reductions in mortality (N = 1688).51,63,66
You're wasting your time with Diesel because he won't ever believe any studies supporting Ivermectin.
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Old 11-09-2021, 09:55 PM
 
16,547 posts, read 8,584,349 times
Reputation: 19383
Quote:
Originally Posted by Starglow View Post
You're wasting your time with Diesel because he won't ever believe any studies supporting Ivermectin.
Maybe he should see post #28 in this thread;

https://www.city-data.com/forum/poli...t-magic-3.html


`
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Old 11-10-2021, 06:08 AM
 
5,517 posts, read 2,402,623 times
Reputation: 2159
Quote:
Originally Posted by ukrkoz View Post
The evidence base for ivermectin against COVID-19

To date, the efficacy of ivermectin in COVID-19 has been supported by the following:
  1. Since 2012, multiple in vitro studies have demonstrated that Ivermectin inhibits the replication of many viruses, including influenza, Zika, Dengue, and others.917
  2. Ivermectin inhibits SARS-CoV-2 replication and binding to host tissue through several observed and proposed mechanisms.18
  3. Ivermectin has potent anti-inflammatory properties with in vitro data demonstrating profound inhibition of both cytokine production and transcription of nuclear factor-κB (NF-κB), the most potent mediator of inflammation.3739
  4. Ivermectin significantly diminishes viral load and protects against organ damage in multiple animal models when infected with SARS-CoV-2 or similar coronaviruses.31,32
  5. Ivermectin prevents transmission and development of COVID-19 disease in those exposed to infected patients.4045
  6. Ivermectin hastens recovery and prevents deterioration in patients with mild to moderate disease treated early after symptoms.45,4952,61,62
  7. Ivermectin hastens recovery and avoidance of ICU admission and death in hospitalized patients.45,51,53,6366
  8. Ivermectin reduces mortality in critically ill patients with COVID-19.45,53,63
  9. Ivermectin leads to temporally associated reductions in case fatality rates in regions after ivermectin distribution campaigns.48
  10. The safety, availability, and cost of ivermectin are nearly unparalleled given its low incidence of important drug interactions along with only mild and rare side effects observed in almost 40 years of use and billions of doses administered.75
  11. The World Health Organization has long included ivermectin on its “List of Essential Medicines.”
A summary of the statistically significant results from the above controlled trials are as follows:
Controlled trials in the prophylaxis of COVID-19 (8 studies)
Not sure why you are posting all this. This is in regards to Dr. Kory's Math+ protocol. It has NOTHING to do with Ivermectin. This just goes to show you don't even read before you post and proves your confirmation bias.

At any rate, Invitro studies and animal studies are not evidence Ivermectin works.

Quote:
  1. All 8 available controlled trial results show statistically significant reductions in transmission.
  2. Three RCTs with large statistically significant reductions in transmission rates, N = 774 patients.4446
  3. Five OCTs with large statistically significant reductions in transmission rates, N = 2052 patients.4043,47
Controlled trials in the treatment of COVID-19 (19 studies)
  1. Five RCTs with statistically significant impacts in time to recovery or hospital length of stay.45,49,53,64,65
  2. One RCT with a near statistically significant decrease in time to recovery, P = 0.07, N = 130.54
  3. One RCT with a large, statistically significant reduction in the rate of deterioration or hospitalization, N = 363.49
  4. Two RCTs with a statistically significant decrease in viral load, days of anosmia, and cough, N = 85.57,60
  5. Three RCTs with large, statistically significant reductions in mortality (N = 695).45,60,65
  6. One RCT with a near statistically significant reduction in mortality, P = 0.052 (N = 140).53
  7. Three OCTs with large, statistically significant reductions in mortality (N = 1688).51,63,66
You should probably check your studies here instead of copying and pasting. There are multiple studies here that were either using many other treatments in conjunction with ivermectin, are retracted, have flawed data, or are very low quality.

Last edited by Diesel350z; 11-10-2021 at 06:18 AM..
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Old 11-10-2021, 06:32 AM
 
6,829 posts, read 2,115,831 times
Reputation: 2591
Let's wait for Kory's response.

MATH+ protocol does not involve Ivermectin, that's IMASK protocol.
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Old 11-10-2021, 06:45 AM
 
78,337 posts, read 60,527,398 times
Reputation: 49625
Quote:
Originally Posted by Starglow View Post
You're wasting your time with Diesel because he won't ever believe any studies supporting Ivermectin.
Thread isn't about Ivermectin. Whomp whomp.
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Old 11-10-2021, 07:09 AM
 
Location: Oklahoma
17,775 posts, read 13,665,953 times
Reputation: 17808
Quote:
Originally Posted by Diesel350z View Post
Not sure why you are posting all this. This is in regards to Dr. Kory's Math+ protocol. It has NOTHING to do with Ivermectin. This just goes to show you don't even read before you post and proves your confirmation bias.

At any rate, Invitro studies and animal studies are not evidence Ivermectin works.

You should probably check your studies here instead of copying and pasting. There are multiple studies here that were either using many other treatments in conjunction with ivermectin, are retracted, have flawed data, or are very low quality.
I guess he didn't realize that he was citing the bibliography of a paper by the author you were referring to in your OP.
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