Meeting kindred spirits in general will be somewhat easier in Roanoke on the basis that there are simply more people living in the Roanoke metro. There may be exceptions though depending on how you like to spend your free time.
My experience as a non-churchgoing person is that if you have school-age children then you may end up making most of your friends through the school's social network.
If you love the outdoors, both places are great options, but there is a huge and growing social network for outdoor activities you can tap into through the Roanoke Outdoors group on Facebook. Just search for "roanoke outdoors" on FB.
We have kids and just joined Kids in the Valley Adventuring, which is a great group. A bunch of parents and kids spent yesterday afternoon at Thrasher Park. We met some new folks, and the kids had fun!
KIVA Gallery! - Play Day - Thrasher Park - Jun. 14th, 2009/ D7X4651-2
Sean