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Chica_Go, I'd head South on I-55 to St. Louis, Take I-44 over to Oklahoma City (OKC), Get on I-40 West in OKC and run that all the way to I-15 in CA. Take I-15 at Barstow to the I-215 at the bottom of Cajon Pass (Just N of San Bernardino) into San Diego. Have a GREAT trip!
Notes:
I-44 from the OK/MO border to OKC is a toll road; not very expensive, though. In OKC, the John Kilpatrick Toll Road may be worth the money to avoid downtown OKC. At Vinita, OK, there's a HUGE MCDonald's in the median of the highway.
Weather is quickly changeable on I-40 at Flagstaff Mountain in AZ; kep an ear to your weather radio.
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