Welcome to City-Data.com Forum!
U.S. CitiesCity-Data Forum Index
Go Back   City-Data Forum > General Forums > Science and Technology
 [Register]
Please register to participate in our discussions with 2 million other members - it's free and quick! Some forums can only be seen by registered members. After you create your account, you'll be able to customize options and access all our 15,000 new posts/day with fewer ads.
View detailed profile (Advanced) or search
site with Google Custom Search

Search Forums  (Advanced)
 
Old 10-16-2012, 05:40 PM
 
Location: Texas
5,068 posts, read 10,129,228 times
Reputation: 1651

Advertisements

Nanoparticles have shown great promise in the targeted delivery of drugs to cells, but researchers at the University of Georgia have refined the drug delivery process further by using nanoparticles to deliver drugs to a specific organelle within cells.


By targeting mitochondria, often called “the powerhouse of cells,” the researchers increased the effectiveness of mitochondria-acting therapeutics used to treat cancer, Alzheimer’s disease and obesity in studies conducted with cultured cells.


“The mitochondrion is a complex organelle that is very difficult to reach, but these nanoparticles are engineered so that they do the right job in the right place,” said senior author Shanta Dhar, an assistant professor of chemistry in the UGA Franklin College of Arts and Sciences.
Reply With Quote Quick reply to this message

 
Old 10-23-2012, 11:49 AM
 
Location: Pueblo - Colorado's Second City
12,262 posts, read 24,455,268 times
Reputation: 4395
Thanks for posting! The implications of this will be profound!
Reply With Quote Quick reply to this message
 
Old 10-28-2012, 06:34 PM
 
Location: US Empire, Pac NW
5,002 posts, read 12,356,425 times
Reputation: 4125
Quote:
Originally Posted by Brian.Pearson View Post
Nanoparticles have shown great promise in the targeted delivery of drugs to cells, but researchers at the University of Georgia have refined the drug delivery process further by using nanoparticles to deliver drugs to a specific organelle within cells.


By targeting mitochondria, often called “the powerhouse of cells,” the researchers increased the effectiveness of mitochondria-acting therapeutics used to treat cancer, Alzheimer’s disease and obesity in studies conducted with cultured cells.


“The mitochondrion is a complex organelle that is very difficult to reach, but these nanoparticles are engineered so that they do the right job in the right place,” said senior author Shanta Dhar, an assistant professor of chemistry in the UGA Franklin College of Arts and Sciences.

DARPA has been looking into this for years. Take a look at "Radical Evolution" by Joel Garreau.

Though this is very cool! Of course the first application will be in the military. If you can increase the effectiveness of the mitochondria, you can deploy troops "mean and plump" instead of "lean and mean" because the mitochondria will break down the fat. And the food they do carry will last them longer.

Later on, I can imagine that they could use a method to create an "armor" around synapses in the brain.

And finally, a lot of futurists predict that we'll eventually become cybernetic. I wonder. I personally would like to keep my body, thank you very much. And if I can enhance it to the point that you can enhance the BEING, and not just the SUBSTANCE, I see this technology as being one option.

And that's what I see some of the latest tech being developed as offering. Options.
Reply With Quote Quick reply to this message
 
Old 10-30-2012, 10:40 AM
 
Location: Texas
5,068 posts, read 10,129,228 times
Reputation: 1651
Quote:
Originally Posted by eskercurve View Post
DARPA has been looking into this for years. Take a look at "Radical Evolution" by Joel Garreau.

Though this is very cool! Of course the first application will be in the military. If you can increase the effectiveness of the mitochondria, you can deploy troops "mean and plump" instead of "lean and mean" because the mitochondria will break down the fat. And the food they do carry will last them longer.

Later on, I can imagine that they could use a method to create an "armor" around synapses in the brain.

And finally, a lot of futurists predict that we'll eventually become cybernetic. I wonder. I personally would like to keep my body, thank you very much. And if I can enhance it to the point that you can enhance the BEING, and not just the SUBSTANCE, I see this technology as being one option.

And that's what I see some of the latest tech being developed as offering. Options.
Very interesting about the "armor" around the synapses in the brain. Could you go into that a bit further?
Reply With Quote Quick reply to this message
 
Old 10-30-2012, 08:48 PM
 
Location: US Empire, Pac NW
5,002 posts, read 12,356,425 times
Reputation: 4125
Quote:
Originally Posted by Brian.Pearson View Post
Very interesting about the "armor" around the synapses in the brain. Could you go into that a bit further?
According to research, the implications of free radicals in Alzheimer's patients seems to me that what is needed is a protective layer around the synapses of the brain that prevent the plaque from damaged cells accumulating. This has been linked to an increase in the number of free radicals in the brain which helps lead to memory loss.

I was thinking if the mitochondria in the brain could be repaired, and the plaque removed or otherwise healed by the body, then this could help in repairing damaged caused by free radicals in Alzheimer's patients.Frontiers | Brain Mitochondrial Dysfunction in Aging, Neurodegeneration, and Parkinson's Disease | Frontiers in Aging Neuroscience

One method might be to make the mitochondria more efficient in metabolizing Vitamin E. It appears that a diet rich in Vitamin E helps reduce the effects of aging in the brain. The beautiful part is vit E is fat soluble, and if you make the mitochondria more efficient, you thus resolve less vit E you need to protect your brain (or have it go hyperactive and get boosted protection).
Reply With Quote Quick reply to this message
 
Old 11-01-2012, 06:17 PM
 
Location: Texas
5,068 posts, read 10,129,228 times
Reputation: 1651
My wife has some arteriosclerosis. I'd be interested in checking that out, further, but this could be down the road before anything gets done.
Reply With Quote Quick reply to this message
Please register to post and access all features of our very popular forum. It is free and quick. Over $68,000 in prizes has already been given out to active posters on our forum. Additional giveaways are planned.

Detailed information about all U.S. cities, counties, and zip codes on our site: City-data.com.


Reply
Please update this thread with any new information or opinions. This open thread is still read by thousands of people, so we encourage all additional points of view.

Quick Reply
Message:


Over $104,000 in prizes was already given out to active posters on our forum and additional giveaways are planned!

Go Back   City-Data Forum > General Forums > Science and Technology
Similar Threads

All times are GMT -6.

© 2005-2024, Advameg, Inc. · Please obey Forum Rules · Terms of Use and Privacy Policy · Bug Bounty

City-Data.com - Contact Us - Archive 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37 - Top