Greetings Wrat,
Well, it depends on what you need. It's totaly different for everyone. Where are you living now? If you go to the bankrate web site you can do a cost of living comparison to see what you can live on. The places you mentioned living in are not far from Greenville so your not looking at a long commute.
We live in Northern California (I'm a southerner in heart I was just born in the wrong state) and will be moving to the Anderson or Pickens county in late 2007. And just like you will be able to buy a home outright.
I think you will be ok.
Mark