If you want to live downtown, live on Washington Ave.
IMO, Downtown does not have the best bar scene though. There are 3 or 4 districts that I like better ... but you could not bike to downtown from any of them

. You could take the metro though.
You would not be dissapointed in the least living on Wash Ave, however. I would if I were working downtown.
Good luck with the job opportunity. I would definitely visit Saint Louis first before moving. There are alot of great things about it and there are some not so great things about it. It will fit some people's taste and not others. It's definitely better than Memphis though

.