Well, not exactly the kind of notoriety one looks for, but . . . It seems that Knoxville(#6) and Johnson City(#3) have made the Top Ten List (followed by 90 other offenders) of worst cities for allergies.
This is an annual report put out by the Asthma and Allergy Foundation of America. They judge a cities placement on the list by a number of mitigating factors.
Here is the link to the report on Web.MD. We have heard it said many times that if you have allergies, take care when considering a move to E. TN. However, all of the pluses to life in TN do far outweigh this little bump in the road, in my opinion.

Worst Allergy Cities for Spring Allergies