Definitely know what you're getting into.
My wife and I are in the medical field. We moved to Texarkana from Pittsburgh (the one in PA, Not Pittsburg, TX

) to take an "offer we couldn't refuse." The size of the town was no problem as my wife is from a town of comparable size while I was from one much smaller. However, East Texas is more "Southern" than Texan. Assimilating into "Southern" culture was a bit more difficult for her. I was in the USAF and spent considerable time in the South and Texas, so it wasn't much of a paradigm shift for me. However, seeing as your spouse will be spending more time in the hospital than in your life, it may not seem like much of a change to him.
Paris is a much smaller town at 26K. Everything you might wish to visit isn't a 10-20 min drive anymore - it's a 1.5-2.5 hr drive. It's in the buckle of the bible belt (we're Baptists - so no problem for us). Most locals drive 5-10mph BELOW the speed limit, not 10-25 above (this will get annoying until you adjust).
I've done some locums in Paris & know of a few marriages that have been strained by the move from a "big city" atmosphere, to the more sedate, agrarian, lifestyle that you'll be moving to. Some have decided to break their contract for a move to Dallas or Austin to satisfy a spouses desire to move closer to a more fast-paced lifestyle that their more accustomed to. I know of one vascular surgeon who's decided to enroll his kids in a private school in Dallas (his wife is going there with the kids, while he works @ his practice) to increase his kids opportunities for college choice in the future. This is a guy who lives in Texarkana - 3 school districts (2 quite good), a private (Catholic) school & science magnet school.