Good and bad. As you'll see in many comments, DC can really be 'block by block'. If there is a liquor store on one block that attracts a certain element that may not be present if there was a Starbucks (though you can debate which is worse).
There is a large public housing project at 11th and Penn that doesn't help the area. There are a few other sketchy bits near the Subway (or on a path from the subway to certain blocks).
Take a look at the DC Crime Map and make your call based on what you think your street sense is and tolerance for petty crime in the area.
Metropolitan Police Department