Located two miles west of the city, Outagamie County Airport, one of the fastest-growing airports in Wisconsin, offers service by United Express, Comair/Delta Connection, Northwest Airlink, and Midwest/Express/Skyway Airlines. The airport has nonstop flights to Milwaukee, Atlanta, Cincinnati, and Chicago. In 2000 Northwest upgraded to non-stop service between Appleton and Midwest hubs in Detroit and Minneapolis/Saint Paul; now both turboprop and jet service is available. Additional flights can be taken from Green Bay's Austin Straubel Field just 30 minutes away. Inter-regional bus service is provided by Greyhound Bus Lines, with daily trips to Milwaukee, Green Bay and Stevens Point. Lamers Bus Lines offers one daily departure to the Amtrak station in Milwaukee.
Appleton's main thoroughfares include U.S. Highways 10, 41, and 45. Secondary passages are State Highways 47, 55, 76, 96, 114, 150, and 441. Valley Transit offers local bus service.