Several airports are located in the Santa Ana metropolitan area. The John Wayne Airport, part of the Los Angeles hub, is 5 miles from downtown Santa Ana; it is served by 11 airlines and services 7.5 million passengers each year. The Los Angeles International Airport is 37 miles from downtown; other airports in the immediate area are Fullerton Municipal Airport, Long Beach Airport, and Ontario International Airport.
Four major highways lead into Santa Ana: I-5, the Santa Ana Freeway; S.R. 55, the Costa Mesa Freeway; S.R. 57, the Orange Freeway; and S.R. 22, the Garden Grove Freeway.
The Orange County Transit District operates 23 routes that interconnect with the Regional Transportation District (RTD), an intercity system. Special services are available for the handicapped and the hearing impaired. Centerline light rail currently offers 9.3 miles as part of a 90-mile Rail Master Plan adopted by Orange County; services include a direct line from The Depot at Santa Ana to the John Wayne Airport. The Regional Transportation Center is a hub for Amtrak, intercity buses, urban transit, a future rapid transit system, taxi cabs, an airport shuttle, and other transportation services.