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Best solution for me was to live right beside the ocean in New England. Winters were horrible with bad storms and flooding, but the rest of the year was great because it was allergy-free! Nothing grew there, it was just beach sand, some beach grass, wild roses, seaweed, and a few plants in my garden (enriched with real soil.) Now I've moved inland where it is heavily forested and also infested with every type of weed imaginable. Back to allergy shots again and sinus infections and feeling horrible until the first frost comes mid to late October.
I think the best cure for allergies is to live right on the beach if you can. Not too many people are allergic to beach sand, lol. Besides, the further south you go, in general, the more variety of plants there are. North. On a beach.
Not so fast- dust and mold grow in humid climates and people are allergic to those. I am allergic to dust, so there is really no solution for me. When I lived by a beach, I had to keep the dehumidifier running to make sure it didn’t get too humid. Anywhere too dry and the dust flies up into the air.
Living near the ocean won’t work for everyone. I had no allergies in Chicago, but after moving to coastal NC, I developed terrible allergies (mold and dust) and asthma. It keeps me inside most of the year.
I’m on medication and getting allergy shots, but not much has changed. Husband has finally agreed to consider moving further north.
To the OP, consider allergy testing for your wife. There’s no one perfect place to live to avoid allergies. It’s different for each of us. Once she knows what she’s allergic to, you can research possible moves.