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Downtown Oakland is pretty dense and vibrant, especially considering that it's just ten miles away from downtown San Francisco. San Jose has a relatively nice CBD too (a lot more action than many people realize, despite being small for the city size), considering there are two larger and busier CBDs just a 45 minute drive to the north.
Downtown Detroit has held on better than I thought it would, considering all the flight of commerce and wealth that has taken place to edge (suburban) cities such as Southfield and Troy.
Pittsburgh has 2 & 3 largest CBD (Downtown and Oakland) in the state of PA...with an emerging 3rd CBD in the East Liberty the neighborhood where Google is located.
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