The Big 4 of American Cities (NYC, LA, Chicago, etc...)

[BajanYankee]

Originally Posted by atadytic19

But it's the underlying infrastructure as important or more important?

Bay Area: The world owes a great debt of gratitude to the Bay Area. We invented all of the products that serve as the technological foundation of the modern world. The world could not function without our contributions.

*New Jersey enters the chatroom*

[OyCrumbler]

Originally Posted by Boston Shudra

Clinical and full-scale manufacturing of Pfizer’s vaccine happened in the Boston area.

As in first happened? I wasn't aware of that, but that's exciting.

Originally Posted by BajanYankee

Bay Area: The world owes a great debt of gratitude to the Bay Area. We invented all of the products that serve as the technological foundation of the modern world. The world could not function without our contributions.

*New Jersey enters the chatroom*

Sure, that's one way to think about it. The whole thing is how long of a timescale do you want to account for. Obviously, there are going to be quite a few cities in Mesopotamia and the Yellow River Valley if you want to talk about technological foundation of the modern world depending on how you want to define the modern world. These are interesting takes you have, but I think you'll find an even smaller audience in the context of arguing about most important currently than you'd find if arguing for the Bay Area.