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A lot of big cities outside of the LA, SF, Chicago and the Northeast corridor offer great amenities, but the majority if their actual neighborhoods are indistinct and offer little in the way of amenities. Outside of the usual suspects, which city has the best collection of neighborhoods. For the sake of discussion, let's limit this to cities proper.
I voted for San Diego! Not sure if it's the "best" with regard to the poll question, but since I've moved to SD 14 years ago I've been very surprised by how much SD is a city of neighborhoods. The various neighborhoods tend to have distinct cultures and are often separated by geographic features such as hills, canyons, rivers, etc. One of the cool things about SD is that many neighborhoods are named for geographic features e.g. beach, hills, valley, etc. This also makes for a lot of diversity in the neighborhoods from beach 'towns' to hipster hangouts to bedroom communities. Surprisingly, even the climate differs amongst the neighborhoods. Beach neighborhoods are cool and foggy to inland neighborhoods that get sunny and hot.
My pick would either be New Orleans (which I voted for) or San Diego. I like all the small, walk able, and quaint neighborhoods in New Orleans. The beach neighborhoods tend to be my favorite in SD but also the ones closer to and north of downtown area great as well.
I'm gonna go with Seattle. The hilly geography and all the water bodies give the neighborhoods a distinct feel. Capitol Hill, Queen Anne, Ballard, the University District, Fremont, Greenwood, Columbia City (a neighborhood in Seattle), Georgetown, Alki Beach, Alaska Junction etc. All of these neighborhoods feel quite different from each other and all offer a unique experience and good amenities. It almost feels like a lot of Seattle's neighborhoods are small towns with their own downtown/center.
New Orleans would be just behind Seattle, followed by San Diego.
Out of these, I'd pick Baltimore for Fells Point, Federal Hill, Little Italy, and the Inner Harbor. I might have picked St. Louis if it was an option instead, with Central West End, Lafayette Square, Tower Grove, Soulard, Downtown, The Hill, and Benton Park being some of its best neighborhoods. A lot of the other cities I don't know as well neighborhood by neighborhood.
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