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In the last four years, my 23&Me results have changed wildly? Why? I downloaded the report and loaded it into GEDMatch a few months ago and GEDMatch came back with the original results, plus health results that 23&Me didn't detect (but was later diagnosed by doctors... I also did the health reports).
Two people in my family were adopted, they were closed adoptions. I was trying to figure out what my ancestry and health was like. I already have chronic conditions and that's why I tried.
When I first did this, I was 7% Ashkenazi, 30% Eastern European, German, Norwegian, and French. Dad was adopted by an Italian family and there was no Italian. Mom's mother was adopted by an Italian family too. The only biological grandparent was my grandfather and he was Irish. I was 40% Irish, which wasn't a surprise.
NOW, 23 & Me took out the Ashkenazi, German, Norwegian, and French. Added Italian, not much. I'm more Eastern European than Irish.
According to GEDMatch, I'm actually 15% Ashkenazi, 45% Eastern European, and 40% Irish/British. GEDMatch found the Celiac, which 23&Me didn't pick up on. I was diagnosed by a doctor. GEDMatch picked up on conditions I do have, which 23&Me didn't pick up on. It was weird.
In the last four years, my 23&Me results have changed wildly? Why? I downloaded the report and loaded it into GEDMatch a few months ago and GEDMatch came back with the original results, plus health results that 23&Me didn't detect (but was later diagnosed by doctors... I also did the health reports).
Does Ancestry's ancestry change wildly?
Yes, all DNA companies update their ethnicity report periodically. It is only an interpretation of our DNA and is subject to different/changing reference panels and algorithms.
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According to GEDMatch, I'm actually 15% Ashkenazi, 45% Eastern European, and 40% Irish/British.
Gedmatch's admixture calculators are pretty outdated now.
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GEDMatch found the Celiac, which 23&Me didn't pick up on. I was diagnosed by a doctor.
Last I knew, Gedmatch didn't do health reports. Maybe you mean Promethease? In any case, DNA health reports are not diagnostic, even if you got a positive results for Celiac on a DNA test, you would still need a doctor to diagnose you. DNA reports simply provide insight into conditions you might be prone to. It does not mean you definitely have or will develop any conditions you get a positive on, and it doesn't mean you can't have or will never develop conditions you get a negative on. Additionally, the 23andMe DNA test isn't a whole genome sequencing - it only uses a portion of your DNA and might not include all known SNPs that are associated with any particular condition like Celiac.
Yes, all DNA companies update their ethnicity report periodically. It is only an interpretation of our DNA and is subject to different/changing reference panels and algorithms.
Gedmatch's admixture calculators are pretty outdated now.
Last I knew, Gedmatch didn't do health reports. Maybe you mean Promethease? In any case, DNA health reports are not diagnostic, even if you got a positive results for Celiac on a DNA test, you would still need a doctor to diagnose you. DNA reports simply provide insight into conditions you might be prone to. It does not mean you definitely have or will develop any conditions you get a positive on, and it doesn't mean you can't have or will never develop conditions you get a negative on. Additionally, the 23andMe DNA test isn't a whole genome sequencing - it only uses a portion of your DNA and might not include all known SNPs that are associated with any particular condition like Celiac.
Yes, I did Promethease! I guess I will never really know what dad is ethnicity wise and I will never know what mom-mom was. Dad says he's Italian because he was raised by an Italian family. I never connected with it and I rejected that religion when I was 11. I'm changing my religion and I guess at the end of the day, I can be whatever I want and ethnicity probably doesn't matter.
If you test with two companies, say Ancestry and 23andme, your results will differ but your DNA is the same. The companies use different approaches to do the analysis and have different geographic maps and different reference populations. Time passes and the reference populations grow and become more specific. The companies provide customers with an updated report that changes the original results. If a family has a long held notion that they were "German" and initial results confirmed that, future results might show Eastern Europe if the newer reference population shows that result.
That is sort of my family experience as the revised reports come in. We were North Sea people of German culture, language, religion, and in every way imaginable except that we migrated and lived among and inter-married with our West Slavic neighbors along the Baltic coast of what is now Poland so results show Eastern Europe. Knowing history and migration or settlement patterns is important for understanding results. My German results have diminished with each revision.
If you test with two companies, say Ancestry and 23andme, your results will differ but your DNA is the same. The companies use different approaches to do the analysis and have different geographic maps and different reference populations. Time passes and the reference populations grow and become more specific. The companies provide customers with an updated report that changes the original results. If a family has a long held notion that they were "German" and initial results confirmed that, future results might show Eastern Europe if the newer reference population shows that result.
That is sort of my family experience as the revised reports come in. We were North Sea people of German culture, language, religion, and in every way imaginable except that we migrated and lived among and inter-married with our West Slavic neighbors along the Baltic coast of what is now Poland so results show Eastern Europe. Knowing history and migration or settlement patterns is important for understanding results. My German results have diminished with each revision.
Like I said, two people in my family were adopted and they were closed. Mom-mom has been dead for 24 years, so I guess I could search for her birth family. My dad has no interest in it; my grandparents were his parents and he has no interest in finding his birth parents. Although, I don't think he can because when my parents were having some issues, mom asked if they could see the records and it was met with anger, or so I've heard. I was hoping 23&Me could answer some questions.
I guess the only thing I know for certain is I'm Irish/British since my biological grandfather was Irish/British. My biological great grandma emigrated from Ireland to the US in the late 1920's and I still have family in Ireland.
Yet, I would like to know the other half of my puzzle, to make sense of some things. I was born lactose intolerant, that didn't come from the Irish/British family. I'm also the only Celiac in my family, at least that I know of. I was diagnosed after markers for an autoimmune liver disease was found on a blood test. Thank goodness it's only NAFLD and gluten-free helped. The Celiac was found because of my liver. The Ashkenazi I found early on would make sense with the Celiac and lactose intolerance. Maybe the Eastern European would too.
Was it 60 Minutes that did a piece on these DNA companies the other day? In essence, they exist to sell data to pharmaceutical companies so they may develop drugs to "discovered" conditions in your (millions of "yours") DNA.
And the beauty of the business model is that they get YOU to pay for the sample and data collection. And the drug companies pay for the data, too.
Your heritage? Not so important to them.
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