Yes, I've made the trip a few times from Seattle to Georgia and used mapquest primarily and cut directly through the US of A...not using I-5 at all, it's going directly south which is surely wasting time and more important fuel prices and hotels....
Basically I took I-90 from Seattle east toward Idaho...385 miles, then I-29 South toward Iowa..., I-70 to Illinois...I-64 to Kentucky, I-57 to Memphis,
then I-24 to Tennessee to Georgia...I hit a blizzard on I-70 and the freeway was shutdown for 4 days, lived in a hotel with my wife...that stunk..but mother nature has control....semi trucks were everywhere, this was in February timeframe....
Estimated Time: 40 hours 49 minutes Estimated Distance: 2730.82 miles