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Cairo WAS as significant river port--in the 19th century. Being at the confluence of two major rivers just doesn't mean much to a city's importance or economy anymore. Yes, lots of river barges carrying tons of bulk still pass by the town every day, but they don't stop there. No reason to.
The city peaked in population in 1920 and now has less people than in 1860.
Oops, I should’ve included the full statement from Wikipedia. It says “only three cities in the United States ...border two other states on two sides, and its own state on the other two sides.” That’s specifically what makes those cities I mentioned unique.
Dubuque, Iowa, and East Dubuque, Illinois, border on each other and both also border on Wisconsin. And Keokuk. Iowa, borders on Illinois and Missouri, giving Iowa three such cities,, with Sioux City, above..
Among all US counties, Louisiana's parishes, Alaska’s boroughs, and independent cities, none begin with the letter X. However, there are about a half dozen city, town and community names that begin with X.
There are two US cities that border two other states on two sides:
Weirton, WV borders Ohio on the west and Pennsylvania on the east.
Pittsburg, NH borders Maine on the east and Vermont on the southwest.
And there is a third city that might meet this criteria, but it’s uncertain: Hancock, MD appears to be very close to bordering Pennsylvania on the north, and it borders West Virginia on the south.
The Mississippi River generally flows west to east at New Orleans. However, downtown New Orleans sits west of a bend in the river. And the West Riverside neighborhood lies north of the river.
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