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Something to think about for the future: Interstate 57 out of Chicago might see Little Rock as a control city one of these days when that highway gets completed from Missouri into Arkansas. Just speculating, but for that highway, the Missouri segment won't have a major city on it.
I-90 ultimately goes to Boston, but there are a few bigger cities between Cleveland and Boston: Erie, Buffalo, Rochester, Syracuse, Utica, Schenectedy, Springfield. I-80 on the other hand doesn't go through any larger cities between Youngstown and NYC.
The eastbound mileage signs along I-90 in upstate NY will tend to list distance to the next city down the road of the group you mentioned, then distance to either Albany or NYC (or both)
That's a great article. Makes mention of a few of the other examples brought up in this thread, such as Ocean City/Sacramento and Provincetown/Bishop CA
The I-285 and I-75 will also say Tampa, which is a good geographic distance from Atlanta.
El Paso to San Antonio on the I-10 is also quite a distance, as well as Albuquerque to Amarillo.
If this included state routes, I’m pretty sure the Reno Las Vegas stretch would win this. Or somewhere in Alaska.
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