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I'm in Syracuse and we get to the City pretty often. Of course, NYC as the biggest city has its pros and cons. Pros is, well, I'm sure you've heard it all before. The con most new yorkers have is that it is just so damn expensive to stay the night there. We've done it a couple of times as a day trip and its not that bad.
I live in Michigan's Upper Peninsula, born in the Detroit metro area and went to school at Western Michigan. I've actually never been to the city proper of Detroit, even though I was born a little over 15 miles from the downtown. I'd love to check it out someday though, there is some incredible architecture in the city. I've probably been to Chicago more times then I've been to Grand Rapids (not counting traveling through on the way to Kalamazoo), though again I'd love to visit Grand Rapids again. Not having a car and being six hours away from all the major population centers in the State make travel difficult!
When I lived in north-central Wisconsin, I would go to Minneapolis/Saint Paul (2.5 hours) probably about once a month. I never really went to Milwaukee (2.5 hours) because by the time I'd get there, it was only another 90 minutes to Chicago. My first time in Madison (outside a forth grade trip to see the capitol) was when I was 20 years old! I guess I've always been stuck in the Twin Cities orbit.
In NC I've only been to our largest region twice, but I visit the 2nd largest region often.
In Maryland it all depends on what you say the largest region is. DC isn't in our state so should I count it or not? But I lived in Towson, MD and visited the city of Baltimore often.
It used to be every year or every other year, but now it's much less. I haven't been to a city of over 25,000 in a very long time. Most of them are two hours, or more, away.
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