the old road to Pinehurst!
it once directed motorists right from Greensboro to Ramseur, Carthage, and Pinehurst/Southern Pines, and other places that are completely bypassed by 421,
and vice versa
one time it intersected 421 right in greensboro, near forest oaks prior to mid 2000s.
now it's removed from Greensboro city limits altogether
south of greensboro it still exists, near Monnet Road and nc-62 in the Climax area and all points south.
ironically, going northbound, NC-22 is still marked with signage directing motorists to Ramseur and Greensboro, coming from Carthage and Southern Pines.