Yeah, it can be pretty bad and completely debilitating. My GM caught a virus which in the end resulted in Endocarditis, she went from a pretty active old lady who lived alone and mowed her own yard/took care of her household and traveled alot to someone who had to be cared for due to the damage to her heart valve. She was/is not a candidate for a replacement valve. She does ok now but cannot be very active at all, even a trip to the grocery store tends to wear her out.
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