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Old 04-01-2015, 11:35 AM
4,761 posts, read 12,858,065 times
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I've read that the antihistamine Claritin (Loratadine) has an undocumented side effect of reliving pain in some cases. And the mechanism of action is below.

My question is if Claritin would also block the white cell response to the "damaged area" which is causing pain? (As it is blocking the "pain pathways".) And if that is the case, then maybe not a good idea to take this for pain? But if it only blocks the pain and the white cells can still do their job, then this would be better than narcotics perhaps?

Mechanism of action...
"The role of histamine in the body is to act as a inflammatory trigger i.e your body senses that damage is being done to it and due to certain receptors in body tissues it invokes the pain pathways so that a it can help direct immune responses to the areas under attack to enable healing, i.e white blood cells and other compounds involved in the healing processes."

"Claritin acts as an histamine antagonist/inverse agonist, i.e it binds to these certain receptors that histamine binds to in the body, plus blocking the ability for histamine to bind to them. This inactivates the function of histamine in the body on these receptors, in this case it is the activation of the pain pathway and plus stops the pain."

Above from...
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