Anyone stop taking a statin drug because of side effects?
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"A great deal of research– much of it performed with industry support– has sought to expand the population of people eligible for PCSK9 inhibitors."
Try to understand SuzyQ. This is a controversy. The drug companies want everyone to think heart disease is mainly genetic. That means they can sell more drugs.
You ONLY show what supports yours and the drug companies' side.
The idea is to generalize from FH patients to almost everyone else. So everyone needs drugs and lifestyle won't be enough.
If it kills you, does it matter whether it does it directly or indirectly? I am not the one playing with words here.
Yes, it does matter because in many cases you cannot prove that high cholesterol did anything to contribute to a death. You can assume but not prove it.
"A great deal of research– much of it performed with industry support– has sought to expand the population of people eligible for PCSK9 inhibitors."
Try to understand SuzyQ. This is a controversy. The drug companies want everyone to think heart disease is mainly genetic. That means they can sell more drugs.
You ONLY show what supports yours and the drug companies' side.
The idea is to generalize from FH patients to almost everyone else. So everyone needs drugs and lifestyle won't be enough.
Lifestyle is not enough. Forty percent of people with elevated cholesterol cannot control it with lifestyle changes. It does not matter whether it is genetic or not. Elevated cholesterol does the same damage no matter whether it is due to FH or not. FH cholesterol is the same molecule as non-FH cholesterol and behaves the same way in both.
“'I do not think the focus should be on whether someone has "FH" or does not have "FH",' commented Allan Sniderman (McGill University). 'The issue should be whether there is severe hypercholesterolemia, regardless of whether it is "FH" or not "‘FH". That is, the clinical consequences of a markedly elevated LDL-C relate to the markedly elevated level of LDL-C, not to the cause of the marked elevation of LDL.'"
Quote:
Originally Posted by gguerra
Yes, it does matter because in many cases you cannot prove that high cholesterol did anything to contribute to a death. You can assume but not prove it.
Cholesterol is essential to the formation of atherosclerotic plaque and stimulates the inflammatory changes that lead to plaque rupture, clots and resultant heart attacks and ischemic strokes. Therefore, cholesterol contributes to deaths from heart attacks and strokes. Reducing cholesterol reduces the number of deaths from heart attack and stroke.
Lifestyle is not enough. Forty percent of people with elevated cholesterol cannot control it with lifestyle changes. It does not matter whether it is genetic or not.
What research has determined that? One study? Not replicated? Just heresay? Drug company research (marketing)?
Cholesterol is essential to the formation of atherosclerotic plaque and stimulates the inflammatory changes that lead to plaque rupture, clots and resultant heart attacks and ischemic strokes. Therefore, cholesterol contributes to deaths from heart attacks and strokes. Reducing cholesterol reduces the number of deaths from heart attack and stroke.
Doesn't prove anything as in hard evidence. There are far too many variables involved.
Doesn't prove anything as in hard evidence. There are far too many variables involved.
Right. It is important to know what variables may be primary causes. We know cholesterol is somehow involved. Lots of other things are somehow involved. You don't fix a problem by focusing on just one variable, which may be unrelated to the cause.
If lowering cholesterol prevents heart attacks and strokes in patients without FH (and there is no certainty about that, since the drug company "research" is actually just marketing), it is by a tiny amount.
Most of the very small benefit from statins, for non-FH patients, is the anti-inflammatory effect. And no, you don't want to be on anti-inflammatory drugs for life!
You aren't paying attention, as usual. What causes LDL to be elevated? It is only a primary cause in FH. It is MUCH more common for the primary cause to be lifestyle, which leads to insulin resistance, etc.
You need things to be very simple. You don't have any idea how to analyze causality in complex systems.
You are making crap up as usual..
WHERE EXACTLY in the link YOU POSTED does it say LDL is only elevated by lifestyle????
And EVEN if that were true...the link YOU POSTED identifies elevated LDL cholesterol as a PRIMARY RISK FACTOR FOR CARDIOVASCULAR DISEASE...
A FACT you refuse to accept...
You make up causality to fit your erroneous hypotheses....causality that isn't THERE
You can't respond because I'm correct. Too much cholesterol itself does not kill directly. Name me one case where it does.
Diabetes is similar. The only time it can kill you is when your blood sugar goes too high or too low. Most of the time you die from complications of diabetes.
I didn't say "I couldn't respond"
I said your post wasn't "worthy of a response"
Not the same thing.....
Still the case with this feeble attempt to justify your ridiculous assertion...
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