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Here is an important detail often forget about diabetes in relation to COVID. Despite having diabetes, it is not confirmed in anyway that those that had diabetes who died of COVID would have died of diabetes despite COVID. Type-2 diabetics can live another 13-21 years at age 55 (compare to another expected 24 years without) and 4-10 years at age 75 (compared to another 10 years without.) People using diabetes or other pre-existing conditions as for why they died "with COVID" not died from COVID, cherry pick to say how COVID doesn't kill people, when it clearly does. Diabetes is a contributing factor, not the mitigating.
This article, obviously written by someone who wants to believe what you say, can't get around the fact that "good" diet won't make you live longer than your genetic potential, but "bad diet" can shorten your life...That's a subtle but important difference..The same argument applies to exercse, etc. ...Keep in mind that cancer developes in only 10% of smokers-- there are obviously other factors involved besides the smoking.
BTW- genetic mutations are by no means rare. How do you think we got so many different alleles at each locus?..(NEW mutations are less common, although we each carry about ten.) ...Considering that the health of an organ might depend on the working of a couple dozen genes, and that there are multiple alleles possible at each locus, the combinations & permutations of genetic possibilites are huge, so it's very difficult to determine what any given environenntal factor will be for any given individual.
Ask Jim Fix about the value of exercise or Euell Gibbons about the value of diet on longetivty. Each were expert practitoners in those fields, yet each died young. You can't overcome bad genes with lifestyle changes. ...and with good genes, you can abuse the heck out of yourself and still live a long time.
You bring up a good point about diabetes-- That condition affects us in many ways, mostly related to accelerated arteriosclerosis, but also related to the immune (healing) system. Life expectancy of diabetics is only 66 yrs, aso opposed to 79yrs for non-diabetics.
It would be nice if we could control our own destinies, but the truth, dear Caesar, is that it IS in our stars and not in ourselves.
What? I haven't said that good diet will make you live longer than your genetic potential. I don't think anyone has said that.
Your link says the same thing I said. I said,
A combo of epigenetic modifications (diet/lifestyle/environment) and genetic susceptibility is common.
From your link:
A variety of linkages clearly exist between environmental exposures, diet, lifestyle factors, and cancer. Genetic factors also are known to be involved in the predisposition to and development of some cancers.
Studies that combine genetic analysis with assessment of exposures and diet can explain why not everyone exposed to a particular cancer-causing chemical will develop cancer.
The research community is now studying cancer with an expanded and enhanced view of environmental health and exposures that include factors such as diet, lifestyle, metabolic alterations, socioeconomic status, and various environmental exposures.
Epigenetics. We are not doomed to develop chronic diseases we are genetically susceptible or predisposed to, as previously thought.
And cancer is not the only chronic disease. It applies to all of them.
I'm always amazed at the crap that manages to get published in "peer reviewed," supposedly legitimate journals.
Isn't it rather obvious that chronic diseases are increasing because lives are no longer snuffed out early by common childhood infections, starvation, industrial accidents, childbirth and simple pneumonia the way they were until technlogy started to have an impact about a century ago?
Life epenctancy has gone from 48 yrs to 80 yrs over that span. How sick can we be?
The cytokine storm is more than likely a genetically determined reaction, not one influenced to any great degree by environmental factors. Cf- any number of auto-immune diseases that are caused by poorly regulated (from genetic causes) immune systems?--
If I want to know the weather, I just look out the window. I don't need a highly trained weatherman on TV to tell me what to expect. I'm right more often than him.
No it is not obvious at all. Americans are very sick, because of the very unhealthy lifestyle. Life expectancy data is extremely confusing and is used to convince people they can rely on medical interventions to keep them healthy. Instead of common sense lifestyle improvements.
The medical industry likes it when people think diseases are mostly genetic and the only way to survive is to depend on their drugs and surgery.
Compare more traditional societies with modernized industrialized societies and you will see what causes the chronic lifestyle diseases. No, we are not getting sicker because we are getting healthier. Medical industry BS propaganda.
This article, obviously written by someone who wants to believe what you say, can't get around the fact that "good" diet won't make you live longer than your genetic potential, but "bad diet" can shorten your life...That's a subtle but important difference..The same argument applies to exercse, etc. ...Keep in mind that cancer developes in only 10% of smokers-- there are obviously other factors involved besides the smoking.
BTW- genetic mutations are by no means rare. How do you think we got so many different alleles at each locus?..(NEW mutations are less common, although we each carry about ten.) ...Considering that the health of an organ might depend on the working of a couple dozen genes, and that there are multiple alleles possible at each locus, the combinations & permutations of genetic possibilites are huge, so it's very difficult to determine what any given environenntal factor will be for any given individual.
Ask Jim Fix about the value of exercise or Euell Gibbons about the value of diet on longetivty. Each were expert practitoners in those fields, yet each died young. You can't overcome bad genes with lifestyle changes. ...and with good genes, you can abuse the heck out of yourself and still live a long time.
You bring up a good point about diabetes-- That condition affects us in many ways, mostly related to accelerated arteriosclerosis, but also related to the immune (healing) system. Life expectancy of diabetics is only 66 yrs, aso opposed to 79yrs for non-diabetics.
It would be nice if we could control our own destinies, but the truth, dear Caesar, is that it IS in our stars and not in ourselves.
You are wrong. Societies that don't have our unhealthy sedentary fast food lifestyle don't have an obesity and diabetes epidemic.
Even regular exercise isn;t what it's cracked up tp be. If you've ever done it regularly, how long does it take to get back "out of shape" once you stop? --About 2 weeks. It has no lasting effect.
No one ever said exercise would have a lasting effect. You are supposed to keep doing it! Jeez.
Note that centenarians from various regions of the world don't seem to have any lifestyle factors in common, but they do seem to have increased levels of cetain enzymes (genetically determined and involved in anti-oxidant activity) in common.
Of course there are lifestyle choices that affect disease and longevity, but are minor influences compared to genetic factors. Genetic and environmantal factors work in common-- Eg- excess sugar intake won't cause disease unless occurring in the presence of the diabetic gene complex.
Ironically, susceptibility to epigenetic modification is itself genetically determined.
Note that centenarians from various regions of the world don't seem to have any lifestyle factors in common, but they do seem to have increased levels of cetain enzymes (genetically determined and involved in anti-oxidant activity) in common.
Those populations do have something in common: Ancestral diets and lifestyles. Diets of fresh, whole, local and seasonal foods, fermented local foods, and more active lifestyles. As populations like this around the world have replaced part of their ancestral diets with Western style foods, incidences of chronic illnesses have increased like cancer, cardiovascular disease, diabetes, autoimmune, alzheimer's, obesity, arthritis, and more.
Quote:
Of course there are lifestyle choices that affect disease and longevity, but are minor influences compared to genetic factors. Genetic and environmantal factors work in common-- Eg- excess sugar intake won't cause disease unless occurring in the presence of the diabetic gene complex.
Ironically, susceptibility to epigenetic modification is itself genetically determined.
That's why I support personalized diets.
No one does well on a Western style diet no matter the genetic makeup. It's more about health, independence, and quality of life than longevity.
No it is not obvious at all. Americans are very sick, because of the very unhealthy lifestyle. Life expectancy data is extremely confusing and is used to convince people they can rely on medical interventions to keep them healthy. Instead of common sense lifestyle improvements.
The medical industry likes it when people think diseases are mostly genetic and the only way to survive is to depend on their drugs and surgery.
Compare more traditional societies with modernized industrialized societies and you will see what causes the chronic lifestyle diseases. No, we are not getting sicker because we are getting healthier. Medical industry BS propaganda.
Right. We've successfully stamped out many acute diseases such as childhood infectious diseases and overall infectious diseases, along w/ improved safety (seatbelts) and industrial safety (oversight, etc.), but chronic disease is still a threat to longevity.
Risk for cancer, heart disease and diabetes Type 2 can be reduced by lifestyle measures.
One study. Healthy lifestyle can offset genetic propensity of heart disease, specifically CAD.
No one does well on a Western style diet no matter the genetic makeup. It's more about health, independence, and quality of life than longevity.
Read the Wiki article-- no commonality in lifestyle.
In regards no one does well on a western diet-- My maternal grand mother was 5'2" and weighed 350. She finally pooped out at age 92. My paternal grand mother was 5' even and weighed 280. She died in her sleep at age 86..Neither ever took a pill nor spent a day in the hosp in their lives. Between them, they had 14 kids.
Anecdotal, yes, but my professional experience will also bear witness to the fact that genetic factors cannot be superceded by lifestyle choices.
I will concede that, since most of us don't actually know what genes we have, it makes sense to assume they're bad and make the lifestyle choices that will aggravate the bad genes the least.
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