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This is why I won't get the vaccine. I am type "O" and by and large, I never get sick. I just have a sneaking suspicion that it is hard to get me infected with almost any virus.
For 15 months the only two changes in my life is
- not going to work every day
- wearing a thin piece of cloth over my face when I go into public.
Haven't gotten infected in a highly populated area. Meanwhile some people get it going to the store.
You get infected, don't have symptoms, and don't know about it like most people. You're just infected for a shorter period of time.
There's no correlation between blood type and risk.
You really want to get your medical advice from politicians?
As far as antibodies as therapies the latest on convalescent plasma treatments show it is ineffective in treatment.
Convalescent Plasma Flops in High-Risk COVID Outpatients
— SIREN-C3PO trial continues the death song for once-promising treatment
Plasma transfusions from COVID-19-recovered patients didn't prevent progression of the same infection in high-risk adults outside the hospital setting, the SIREN-C3PO trial showed, knocking yet another nail into the coffin for convalescent plasma.
Disease progression came to a similar 30.0% in the convalescent-plasma group and 31.9% in the placebo group, with a nonsignificant Bayesian posterior probability of superiority for the treatment (0.68), reported Clifton Callaway, MD, PhD, of the University of Pittsburgh, and colleagues in the New England Journal of Medicine.
"That was surprising to us," Callaway said in a press release from the National Heart, Lung, and Blood Institute (NHLBI), which was one of the trial sponsors. "As physicians, we wanted this to make a big difference in reducing severe illness and it did not."
No benefits emerged among secondary outcomes either, and the mortality risk actually went in the wrong direction (five deaths with plasma vs one with placebo).
While earlier or more geographically targeted administration might have made a difference, Callaway's group noted, it's also possible that "host factors and other aspects of the host response to the infection may be more important than humoral [antibody-mediated] immunity for determining the natural history of the illness."
These are studies on HIGH risk Covid patients who, by the way, were prioritized for the vaccine MONTHS ago. If they wanted the vaccine, they got it.
The monoclonal antibodies have been shown to minimize symptoms of the virus when administered early on. You can't treat a healthy 20 year old kid like his 90 year old grandpa in a nursing home.
Common sense tells us that having lifelong natural immunity to a virus would be preferable than having to get boosters every 6 months or a new vaccine every time a new variant is discovered.
DeSantis is not pulling this stuff out of his arse, he IS following the science, he is listening to medical scientists and he is reading up on the studies. As a politician he is determined to provide his constituents with the best treatment options possible. That isn't being "political" anymore than protecting our vulnerable citizens in nursing homes was him being "political" - that is DeSantis being a decent human being.
The vaccines provide protection by stimulating the production of neutralizing antibodies and T cells.
How can mRNA vaccine effectiveness have significant attrition vs infections but little vs hospitalizations?
Simplified
Prevent infections: neutralizing antibodies. Like System 1 thinking, fast, reflexive
Prevent pneumonia/severe illness: T cells, like System 2 thinking (Kahneman)
These are studies on HIGH risk Covid patients who, by the way, were prioritized for the vaccine MONTHS ago. If they wanted the vaccine, they got it.
The monoclonal antibodies have been shown to minimize symptoms of the virus when administered early on. You can't treat a healthy 20 year old kid like his 90 year old grandpa in a nursing home.
Common sense tells us that having lifelong natural immunity to a virus would be preferable than having to get boosters every 6 months or a new vaccine every time a new variant is discovered.
DeSantis is not pulling this stuff out of his arse, he IS following the science, he is listening to medical scientists and he is reading up on the studies. As a politician he is determined to provide his constituents with the best treatment options possible. That isn't being "political" anymore than protecting our vulnerable citizens in nursing homes was him being "political" - that is DeSantis being a decent human being.
A decent human being will do everything to prevent infection inclusive of mask wearing, eliminate social gatherings and promote vaccines rather than completely rely on treatment as their primary line of defense against this virus.
I have problems with vague terms such as monoclonal antibodies. There are several monoclonal antibodies and there's several viral mutants out there and differing patient populations.
"Among hospitalized patients with severe COVID-19, IDSA recommends against bamlanivimab monotherapy.
NIH guidelines recommend the use of bamlanivimab 700 mg plus etesevimab 1,400 mg OR casirivimab 1,200 mg plus imdevimab 1,200 mg for outpatients with mild to moderate COVID-19 who are at high risk of clinical progression.
NIH recommends against the use of monoclonal antibodies in patients who are hospitalized because of COVID-19, except in a clinical trial. However, they state the combination should be considered for persons with mild to moderate COVID-19 who are hospitalized for a reason other than COVID-19 but who otherwise meet the EUA criteria. "
Where are the studies showing the efficacy of monoclonal antibodies against the Delta variant?
People who do not want to promote mitigating steps want to promote any and all treatment options and proclaim a cure at every corner in order to cover their behind with rising hospitalizations. I am surprised they didn't bring back hydroxychloroquine as cure.
A decent human being will do everything to prevent infection inclusive of mask wearing, eliminate social gatherings and promote vaccines rather than completely rely on treatment as their primary line of defense against this virus.
I have problems with vague terms such as monoclonal antibodies. There are several monoclonal antibodies and there's several viral mutants out there and differing patient populations.
"Among hospitalized patients with severe COVID-19, IDSA recommends against bamlanivimab monotherapy.
NIH guidelines recommend the use of bamlanivimab 700 mg plus etesevimab 1,400 mg OR casirivimab 1,200 mg plus imdevimab 1,200 mg for outpatients with mild to moderate COVID-19 who are at high risk of clinical progression.
NIH recommends against the use of monoclonal antibodies in patients who are hospitalized because of COVID-19, except in a clinical trial. However, they state the combination should be considered for persons with mild to moderate COVID-19 who are hospitalized for a reason other than COVID-19 but who otherwise meet the EUA criteria. "
Where are the studies showing the efficacy of monoclonal antibodies against the Delta variant?
People who do not want to promote mitigating steps want to promote any and all treatment options and proclaim a cure at every corner in order to cover their behind with rising hospitalizations. I am surprised they didn't bring back hydroxychloroquine as cure.
Where were the studies before Florida proved that kids could, in fact, go back to their physical schools, learn and participate in activities with their peers and socialize like kids are supposed to socialize....??
The data suggested that kids were not high risk from the virus and wise governors reopened schools in their states...and there wasn't mass death and hysteria in spite of what some people seemed to be salivating to see.
The monoclonal antibodies are most effective at the earliest stages of the virus which would not be upon hospitalization with severe symptoms.
The sheer number of people who have been re-infected after previously having Covid puts the lie to that.
Age, sex, and medical condition has a lot to do how well your immune system can mount a defense and how long the antibody levels are maintained and T cells are generated. Women tend to produce T cells later into life than men. T cell production starts falling off in the early twenties.
Epidemiologist thinks SARS-COVID-19 will last forever, everyone will have to get vaccinated, asymptomatic cases will have to be isolated, and Delta will quickly run out of people to infect
Once vaccinated or infected, protection from contracting the virus will likely wane fairly quickly for most people, as it does with other coronaviruses, while protection from serious illness will likely be long lasting.
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